Anti-tuberculosis Conjugates Based on Polysaccharides

Shomurotov Shavkat Abduganievich; Mamatmusaeva Nilufar Erkinovna; Sagdullaev Bakhodir Takhirovich; Turaev Abbaskhan Sabirkhanovich

Authors

Shomurotov Shavkat Abduganievich Institute of Bioorganic chemistry UzAS, PhD, Department of Chemistry of Polysaccharides
Mamatmusaeva Nilufar Erkinovna Tashkent Pharmaceutical Institute, PhD
Sagdullaev Bakhodir Takhirovich Institute of Bioorganic chemistry UzAS, DSc, Department of Chemistry of Polysaccharides
Turaev Abbaskhan Sabirkhanovich Institute of Bioorganic chemistry UzAS, DSc,akademik

Keywords:

polymeric complexes, tuberculosis, prolongation, ethambutol

Abstract

The research on the synthesis of polymeric complexes of polygalacturonic acid with anti-TB preparations having antituberculosis activity was conducted. The structures were ascertained and studied the physicochemical properties of polymeric systems. Pharmacotoxicological studies have shown that polymeric complexes are less toxic than their low molecular analogues and Mycobacterium of tuberculosis show high sensitivity to the prepared preparations.