The G308A Polymorphism of the Tumor Necrosis Factor-alpha Gene and the Inflammatory Mechanism of Chronic Venous Insufficiency of the Lower Extremities

Authors

  • S.A. Sharifbaev Andijan State Medical Institute, Andijan, Institute of Immunology and Human Genomics, Tashkent, Uzbekistan
  • V.A.Aleynik Andijan State Medical Institute, Andijan, Institute of Immunology and Human Genomics, Tashkent, Uzbekistan
  • E.A.Vasilevskiy Andijan State Medical Institute, Andijan, Institute of Immunology and Human Genomics, Tashkent, Uzbekistan
  • O.T.Dadabaev

Keywords:

traumatic brain injury, gene polymorphism, superoxide dismutase 2

Abstract

Oxidative stress is a core mechanism of secondary injury after traumatic brain injury (TBI). Mitochondrial manganese superoxide dismutase, encoded by SOD2, is the principal defence against the superoxide radical, and the common Ala16Val polymorphism (rs4880) alters import of the enzyme into mitochondria and its protective capacity. We aimed to determine the distribution of SOD2 rs4880 in patients with TBI, to relate it to serum malondialdehyde (MDA) as a marker of lipid peroxidation, and to assess its association with oxidative-stress-related secondary complications and 6-month functional outcome. The rare APOE variant rs769452 was examined as an exploratory secondary analysis only.

Downloads

Published

2026-04-22

Issue

Vol. 54 (2026): ESH

Section

Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

How to Cite

The G308A Polymorphism of the Tumor Necrosis Factor-alpha Gene and the Inflammatory Mechanism of Chronic Venous Insufficiency of the Lower Extremities . (2026). Eurasian Scientific Herald, 54, 36-43. https://geniusjournals.org/index.php/esh/article/view/7619