The G308A Polymorphism of the Tumor Necrosis Factor-alpha Gene and the Inflammatory Mechanism of Chronic Venous Insufficiency of the Lower Extremities

Authors

  • E. A. Vasilevskiy Andijan State Medical Institute, Ministry of Health of the Republic of Uzbekistan, Andijan, Uzbekistan

Keywords:

chronic venous insufficiency, TNF-alpha, venous trophic ulcer

Abstract

Tumor necrosis factor-alpha (TNF-alpha) is a multifunctional proinflammatory cytokine implicated in the chronic inflammation that drives venous wall remodeling and trophic complications in chronic venous insufficiency (CVI). The functional promoter polymorphism G308A (rs1800629) may modify susceptibility to the disease and its complicated forms.

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Published

2026-04-28

Issue

Vol. 54 (2026): ESH

Section

Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

How to Cite

The G308A Polymorphism of the Tumor Necrosis Factor-alpha Gene and the Inflammatory Mechanism of Chronic Venous Insufficiency of the Lower Extremities . (2026). Eurasian Scientific Herald, 54, 11-18. https://geniusjournals.org/index.php/esh/article/view/7613