Distribution And Clinical Significance of Microdeletions in The AZF Region of The Y Chromosome in Male Infertility

Kurbonova Zumrad Ch; Saifutdinova Zukhra A; Yarmukhamedov Alisher S; Dulanova Dilobar; Sadikova Nigora M; Islamova Zulfiya S

Authors

Kurbonova Zumrad Ch Tashkent State Medical University Institute of Human Immunology and Genomics, Academy of Sciences of the Republic of Uzbekistan
Saifutdinova Zukhra A Tashkent State Medical University Institute of Human Immunology and Genomics, Academy of Sciences of the Republic of Uzbekistan
Yarmukhamedov Alisher S Tashkent State Medical University Institute of Human Immunology and Genomics, Academy of Sciences of the Republic of Uzbekistan
Dulanova Dilobar Tashkent State Medical University Institute of Human Immunology and Genomics, Academy of Sciences of the Republic of Uzbekistan
Sadikova Nigora M Tashkent State Medical University Institute of Human Immunology and Genomics, Academy of Sciences of the Republic of Uzbekistan
Islamova Zulfiya S Tashkent State Medical University Institute of Human Immunology and Genomics, Academy of Sciences of the Republic of Uzbekistan

Keywords:

AZF, microdeletion, male infertility, azoospermia

Abstract

This article examines various types of microdeletions in the AZF region of the Y chromosome and their impact on male infertility. Particular attention is given to the prevalence of AZF microdeletions among patients with azoospermia and oligozoospermia, as well as their clinical manifestations. Data are presented on the prevalence of AZFa, AZFb, and AZFc microdeletions and their effects on male reproductive function. The primary focus is on the pathogenesis, molecular mechanisms, and diagnosis of these abnormalities. For each type of microdeletion, clinical features, diagnostic methods, and treatment approaches using assisted reproductive technologies are described