Eurasian Medical Research Periodical (EMRP) is an Open Access, Peer Reviewed, International, Refereed, Scientific Journal that publishes original research and review articles related to diverse areas of Medical Research Advancements etc. The main objective of Eurasian Medical Research Periodical (EMRP) is to offer an intellectual platform to the international scholars and it aims to promote interdisciplinary studies in Medical field. All manuscripts must be prepared in English language and subject to a rigorous peer-review process. The scope of the journal is not limited to Bioethics, Chronic non-communicable diseases (NCDs), Climate change, Deafness and other communication disorders, Eye disease, vision health and blindness, Global health security, Household air pollution., Implementation science etc. ISSN (E): 2795-7624 Journal Impact Factor: 8.120
Topographic And Anatomical Pathways Of Tumor Dissemination In The Female Reproductive Organs
The anatomy of the female pelvis and reproductive organs constitutes a highly complex topographic–anatomical system that plays a pivotal role in understanding the clinical behavior and dissemination patterns of malignant tumors. Accurate knowledge of pelvic anatomy is of particular importance in gynecologic oncology, where surgical strategy, the extent of lymphadenectomy, identification of metastatic routes, and prognostic assessment are directly influenced by individual variations in vascular supply, lymphatic drainage, organ syntopy, and fascial and cellular compartments.
Copyright (c) 2025 https://creativecommons.org/licenses/by-nc/4.0
Evaluation of the Effectiveness of Immunotherapy in Combination with Conventional Treatment Modalities in Early-Stage Breast Cancer
Breast cancer remains the most frequently diagnosed malignant disease among women worldwide and continues to represent a major cause of cancer-related morbidity and mortality. Despite significant advances in screening, early detection, and multidisciplinary treatment, breast cancer poses ongoing clinical challenges due to its biological heterogeneity and variable response to therapy. Early-stage breast cancer, generally defined as stages I–II according to the TNM classification, is associated with favorable survival outcomes; however, a proportion of patients still experience disease recurrence, progression, or treatment-related toxicity
Analysis Of The Effectiveness Of Total Neoadjuvant Therapy In The Treatment Of Patients With Pancreatic Cancer
Pancreatic cancer remains one of the most aggressive and lethal malignancies in modern oncology and continues to pose a major clinical challenge worldwide. Pancreatic ductal adenocarcinoma (PDAC) accounts for more than 90% of all pancreatic malignancies and is characterized by rapid disease progression, early metastatic spread, and resistance to many conventional treatment modalities. Despite representing a smaller proportion of overall cancer incidence, pancreatic cancer ranks among the leading causes of cancer-related mortality, with five-year survival rates remaining below 15% in most populations. This unfavorable prognosis reflects a combination of late diagnosis, complex tumor biology, and limited therapeutic effectiveness
Akhmadzhanov Elmurodjon Burkhanidinovich
Radiological Approaches to Improve Detection of Delayed Hip Joint Complications in Post-COVID Patients
The objective of this study is to improve the diagnostic effectiveness of radiological methods in identifying late-stage post-COVID pathologies of the hip joint. This includes defining specific radiological features and patterns that characterize these complications, thereby aiding in early detection, accurate staging, and appropriate management of postCOVID hip joint diseases. Timely and precise diagnosis is essential to prevent progression to severe joint damage and reduce the risk of disability.
Optimizing Acute Pyelonephritis Diagnosis through Doppler Ultrasound Imaging
This article describes the way of improving the diagnosis of cute pyelonephritis, which is a bacterial infection of the renal pelvis and parenchyma most commonly seen in young women. It remains common and continues to have significant morbidity in certain groups of patients, using doppleroghraphy.
Ultrasound-Based Assessment in the Diagnosis of Hydronephrosis
Hydronephrosis refers to an abnormal enlargement of the renal pelvicalyceal system resulting from obstruction or disturbance of normal urinary drainage. This condition may present in either acute or chronic forms and, if not identified and managed promptly, can progress to permanent renal impairment and eventual kidney failure. Ultrasonography is widely recognized as the primary imaging technique for assessing hydronephrosis due to its broad accessibility, noninvasive nature, affordability, and absence of ionizing radiation. The aim of the present study is to evaluate the clinical significance and diagnostic effectiveness of ultrasound in the identification, differentiation, and follow-up of hydronephrosis across various underlying causes
A Critical Analysis Of The Phases Of Anesthesia In An Organized Health Care System
Anesthesia is a cornerstone of modern surgical practice, enabling pain-free and safe operative procedures. This paper presents a critical analysis of the phases of anesthesia within an organized health care system, emphasizing their clinical significance, safety considerations, and interprofessional coordination. The phases of anesthesia preoperative assessment, induction, maintenance, and recovery are examined in relation to standardized protocols, patient safety measures, and quality assurance frameworks. The study highlights the role of structured health care systems in optimizing anesthetic outcomes through effective communication, evidence-based practice, and continuous monitoring. Challenges such as patient variability, resource limitations, and perioperative risks are critically evaluated, alongside strategies for improvement including adherence to guidelines, technological advancements, and workforce training. By analyzing anesthesia care across its phases, the study concluded that the phases of anesthesia preoperative assessment, induction, maintenance, and recovery are interdependent components of safe and effective anesthetic care. This critical analysis demonstrates that the success of anesthesia management is largely influenced by the level of organization within the health care system. An organized health care structure supports standardized protocols, skilled personnel, and effective. One of the recommendations made was that, Health care institutions should prioritize comprehensive preoperative evaluations to identify risk factors, optimize patient conditions, and plan individualized anesthetic care.
Modern Aspects Of Etiology, Pathogenesis, Diagnosis And Treatment Of Chronic Generalized Periodontitis
Chronic Generalized periodontitis is one of the most common inflammatory and destructive pathologies of periodontal tissues and is a leading cause of premature tooth loss in adults. The disease is characterized by a multifactorial etiology, complex pathogenesis, and a close relationship with general somatic pathology. This article presents an analysis of current data on the etiological factors and pathogenetic mechanisms of the development of chronic generalized periodontitis. The clinical manifestations of the disease depending on the severity, modern diagnostic methods, including clinical, radiological, and laboratory approaches are considered. Particular attention is paid to the principles of comprehensive treatment, including conservative, surgical, and preventive measures aimed at stabilizing the pathological process and preventing relapse. The need for an individualized and interdisciplinary approach to the management of patients with chronic periodontitis is demonstrated. generalized periodontitis.
Bees Poison And His Joint In Diseases Effect
This article joint diseases in treatment bees healing of poison ( apitoxin ). effect him to the joints and to the organism effect effect will be lit. Bees by calling treatment the main type of treatment methods advantages is displayed .
Diastolic Dysfunction of the Left and Right Ventricles in Patients with Ischemic Heart Disease at the Early Stages of Chronic Heart Failure
The concept of “diastolic dysfunction” is based on both structural and functional remodeling of cardiomyocytes and the interstitial matrix, leading to increased myocardial stiffness [2,4]. Unlike systole, during which Ca²⁺ ions are actively released from the sarcoplasmic reticulum into the cytosol, myocardial relaxation is an energy-dependent process associated with the active transport of Ca²⁺ ions back into the sarcoplasmic reticulum against a concentration gradient [10]. This mechanism explains why disturbances in myocardial relaxation occur earlier than systolic dysfunction, particularly under conditions of myocardial ischemia in ischemic heart disease (IHD) [3,6,9]. The mechanisms underlying impaired diastolic function in IHD can be conventionally divided into two categories: disorders of active relaxation caused by the development of cardiosclerosis and those associated with myocardial ischemia
A Clinical Study Of The Method Of Early Diagnosis Of Coronary Heart Disease
Recently, the issue of early diagnosis of coronary heart disease (CHD) remains the most urgent task of cardiology. The gas analytical method for the analysis of exhaled air (EA) is a new approach to solving this problem [1,5,11]. Our clinical studies of this technique, used to develop a non-invasive method for the diagnosis of coronary heart disease, have led to the following main results: CHD is accompanied by impaired metabolism of biogenic amines [6], volatile biogenic amines are found in the composition of explosives in patients with CHD [1, 2], the content of diethylamine in explosives increases most significantly in patients with postinfarction cardiosclerosis (PICS) [7], secondary amines (SA) can be formed as a result of the reduction of Schiff bases (SHO) under acidosis conditions in the cellular sarcosomes of the cardiac muscle [8,9]. However, the nature of the dependence of the kinetic parameters of SA formation on the degree and scale of ischemic myocardial zones remains unclear.
Osteocalcin As A Marker Of Bone Metabolism Disorders In Children With Juvenile Idiopathic Arthritis
To determine the relationship between osteocalcin and markers of inflammation and bone metabolism in children with juvenile idiopathic arthritis (JIA).
Tumors Of The Head And Neck: Detection At Stage T Using Modern Imaging Techniques
Tumors of the head and neck are characterized by an aggressive course and a high risk of late diagnosis. Despite advances in oncology, most patients are admitted to specialized centers at stages T2–T4, when the effectiveness of treatment is significantly reduced. The detection of tumors at the T₀ stage, when there are no clinical manifestations yet, but morphological and metabolic changes are already forming, is a key area of modern oncorentgenology . The article discusses the possibilities of magnetic resonance imaging (MRI), computed tomography (CT) and positron emission tomography (PET/CT) in the diagnosis of head and neck tumors in the early stages. The results of clinical observations are presented, showing that the use of multiparametric MRI and hybrid technologies can increase the detectability of subclinical forms up to 92%.
Internet And Sleep Hygiene: Impact On Youth Health
This article analyzes the role of modern digital technologies, particularly the Internet, in the lifestyle of young people and its interrelation with sleep hygiene. While the educational and communicative opportunities of the Internet positively influence the intellectual development of youth, excessive and uncontrolled use may lead to sleep disturbances, as supported by scientific sources and observations. In particular, prolonged screen exposure at night can reduce melatonin secretion, disrupt the biological clock, and negatively affect cognitive and physical performance. The article also highlights the fundamental principles of sleep hygiene and their importance for youth health, psychological stability, and academic performance. Hygienic recommendations for the rational use of the Internet and maintaining proper sleep hygiene are provided. The study results demonstrate the relevance and practical significance of hygiene sciences in promoting a healthy lifestyle among young people.
Evaluation of sensitivity and specificity of tests for breast cancer
Breast cancer (BC) is one of the most common malignant neoplasms in women worldwide and a leading cause of cancer-related mortality. Early diagnosis remains a pressing issue, as treatment effectiveness and survival prognosis directly depend on the stage at which the tumor is detected. The aim of this study was to evaluate the diagnostic accuracy of laboratory and instrumental methods used to detect breast cancer and to determine their optimal combination to improve diagnostic efficiency . The study included data from 150 women undergoing examination for suspected breast cancer. A comparative analysis of the sensitivity and specificity of mammography, ultrasound, magnetic resonance imaging (MRI), and the serological markers CA 15-3 and CEA was conducted. Morphological confirmation of the diagnosis (biopsy) was taken as the "gold standard." The results showed that MRI achieved the highest sensitivity (95%), while mammography and ultrasound remained the mainstays of primary screening (86% and 80%, respectively). The combined use of instrumental methods and laboratory markers achieved a sensitivity of 97% and a specificity of 92%, significantly increasing diagnostic accuracy . Thus , the study confirms that the integration of various diagnostic approaches ensures maximum reliability in the early detection of breast cancer and can serve as the basis for optimizing screening algorithms and clinical diagnostics.
Head and neck cancer and factors predisposing to it
This article presents current data on the incidence, risk factors, and pathogenetic mechanisms of head and neck cancer (HNC). An analysis of the main predisposing factors is provided, including tobacco smoking , alcohol consumption, viral infection (in particular, human papillomavirus), and occupational and environmental exposures. Genetic and epigenetic features that contribute to epithelial malignancy are considered. Particular attention is paid to the role of lifestyle factors and early diagnosis of the disease. The results of a retrospective analysis of patients with squamous cell carcinoma of the head and neck are presented
Practical Aspects Of Teaching Medical Terminology In A Modern University
The article presents an in-depth analysis of practical and methodological aspects of teaching medical terminology in modern higher education. It explores the historical background of the discipline’s development, the cognitive and competence-based approaches, and the latest pedagogical technologies used in medical universities. Special attention is paid to the integration of Latin terminology with medical disciplines, the use of digital resources, and the development of terminological thinking and professional speech among students
Algorithm For Examining Pregnant Women With Cervical Pathology To Exclude Cancer
Cervical cancer is the most common malignancy associated with pregnancy. The management of patients with this disease is a unique and complex clinical situation, due to the unpredictable behavior of the tumor during pregnancy and the impossibility of performing all necessary diagnostic and therapeutic measures. It is impossible to perform all necessary diagnostic and therapeutic procedures. Pregnancy is a factor that triggers tumor development due to hormonal changes, decreased immune defenses, improved blood and lymph flow to the reproductive organs, and postpartum cervical changes. Diagnosing cervical cancer during pregnancy is particularly challenging due to the high risk of under- or overdiagnosis, as well as the unavailability of many diagnostic methods. When examining patients, it is necessary to carefully differentiate between normal and pathological growth processes during pregnancy
Comparison of transabdominal and transvaginal ultrasound in the diagnosis of uterine scar failure
The rate of cesarean sections continues to rise worldwide, leading to an increase in the number of pregnant women with uterine scars. One of the most dangerous complications in this category of women is scar failure, which can lead to uterine rupture during pregnancy and childbirth. Ultrasound is the primary method for assessing scar condition, but the optimal approach—transabdominal or transvaginal—remains a matter of debate. In recent years, there has been a steady increase in the number of cesarean sections, which naturally leads to an increase in the proportion of pregnant women with uterine scars. According to WHO data (2021), the cesarean section rate in some countries reaches 25–30%, and this figure is expected to continue to increase. Against this backdrop, the development of optimal methods for diagnosing scar integrity is increasingly important, as scar leakage is a high-risk factor for uterine rupture and perinatal and maternal complications (Silver R.M., 2019; Sentilhes L., 2020). At the same time, transvaginal ultrasound in our study demonstrated significantly higher information yield. It allowed us to accurately determine the thickness of the lower uterine segment in the scar area, assess the shape of the internal contour, and identify minor defects. Specifically, it has been shown that a scar thickness of less than 2.5 mm, detected transvaginally, is associated with a high risk of uterine rupture during childbirth (Bujold E., 2017).
Fungal Diseases in Pistachio Production: Analyzing Their Impact and Exploring Sustainable Solutions Amidst Environmental and Biological Influences
Fungal pathogens pose a significant challenge to pistachio production by affecting both yield and nut quality. This paper examines the multifaceted impact of major fungal diseases—such as Aspergillus flavus, Verticillium dahliae, and Phytophthora spp.—on pistachio orchards, with a focus on environmental, biological, and agronomic influences. Climate change, particularly increased temperatures and altered precipitation patterns, is shown to intensify fungal proliferation and mycotoxin production, thus heightening health and economic risks. Furthermore, soil salinity and microbial interactions significantly affect tree susceptibility and disease dynamics. The paper highlights promising sustainable control strategies, including integrated pest management (IPM), the application of biocontrol agents like Trichoderma spp., use of micronutrients and plant growth regulators, and promotion of microbial diversity in the rhizosphere. Emphasis is placed on a holistic approach that combines biological control, soil health improvement, and climate-adapted practices to enhance pistachio resilience. The findings underscore the need for eco-friendly, multi-dimensional management strategies to ensure the long-term sustainability of pistachio cultivation under increasing environmental stress
Modern approach to diagnostics and management of pregnant women with placenta previa
Placenta previa occurs in 1.5% of all pregnancies and predisposing factors for the development of placentation anomalies are the so-called "diseases of the operated uterus" - dystrophic changes in the endometrium due to the presence of multiple damages to the integrity of the layers of the uterine wall against the background of previous cesarean sections, conservative myomectomies, abortions. It has been established that the course of pregnancy with placenta previa is accompanied by a large number of complications, such as miscarriage, placental disorders, fetal growth retardation syndrome (Shmakov R.G. et al., 2018; Yashchuk A.G. et al., 2020; Bushtyrev A.V. et al., 2016). Despite the fact that in the structure of obstetric bleeding, bleeding associated with uterine hypotension is the most common, bleeding associated with placenta previa ranks among the causes of massive obstetric bleeding
Long-Term Follow-Up Of The Remaining Kidney Function In Patients After Nephrectomy
This article analyzes the long-term dynamics of the remaining kidney function in patients after nephrectomy. The compensatory capacity, time-related changes in functional parameters, and clinical outcomes were studied. Based on the follow-up results, conclusions were drawn regarding the risk of renal failure, arterial hypertension, and metabolic disorders
Uteroplacental Blood Flow Impairment And Mechanism Of Fetal Hypoxia Development In Preeclampsia
This article focuses on the pathophysiological mechanisms of uteroplacental blood flow impairment in preeclampsia and its role in the development of fetal hypoxia. The study included pregnant women diagnosed with preeclampsia, in whom uteroplacental hemodynamic parameters were evaluated using Doppler ultrasound. The analysis demonstrated that impaired spiral artery remodeling, endothelial dysfunction, and placental ischemia play a crucial role in restricting oxygen and nutrient delivery to the fetus. Understanding these mechanisms may contribute to early diagnosis and the development of effective preventive strategies aimed at reducing perinatal morbidity and mortality
Thiazide Diuretics and Their Importance in Cardiac Diseases
Thiazide diuretics are widely used agents in the managing cardiovascular diseases, especially hypertension and chronic heart failure. They act by inhibiting sodium-chloride symporters in the distal convoluted tubule, leading to effective blood pressure reduction. This article explores their mechanism of action, clinical applications, and comparative benefits. A separate section highlights the etiology and classification of heart failure to provide clinical context. The pharmacodynamics and pharmacokinetics of individual thiazides—hydrochlorothiazide, chlorthalidone, indapamide, and metolazone—are discussed in detail. Evidence-based protocols and case studies further demonstrate their clinical value.
The Role Of Internal Audit In Cost Control And Optimization In Sanatorium-Wellness Institutions
This article will consider issues of cost control and optimization in sanatorium-wellness institutions. The author gave an important definition of the role of internal audit in optimizing costs and increasing overall efficiency in the institution. The costs were analyzed by type and special attention was paid to the effective use of Information Technology in the process of their control, Also, methods of cost optimization, strategies of internal audit and its practical results are covered and discussed with examples.
Effect Of Torch Infection On Pregnant Woman And Embryo
TORCH infections pose a significant risk to pregnant women and their unborn children, with the potential for severe complications including miscarriage, stillbirth, congenital anomalies, and long-term neurological disabilities. This comprehensive overview examines the impact of Toxoplasmosis, Other (including syphilis, varicella-zoster virus, and parvovirus B19), Rubella, Cytomegalovirus (CMV), and Herpes simplex virus (HSV) infections during pregnancy. We discuss the epidemiology, transmission, clinical manifestations, diagnosis, management, and prevention strategies for TORCH infections, highlighting the importance of comprehensive prenatal care and public health interventions. Further research is needed to improve our understanding of TORCH infections and develop effective strategies for their prevention and control.
Lavender (Lavandula) Plant's Pharmacognostic and Biological Structure, Species, and Geographical Distribution
This article is dedicated to the pharmacognostic and biological structure of the lavender plant, its species, and its medicinal applications. The paper discusses the historical origins, distribution, morphological features, and main species of lavender, including Lavandula angustifolia (English lavender) and Lavandula intermedia (lavandin). The flowers and other parts of the plant are rich in essential oils, which are widely used in pharmacology, cosmetics, and the perfume industry. Lavender, especially its essential oils, with their calming, antibacterial, and anti-inflammatory properties, play an important role in the production of natural medicinal products. The article also provides information on recent research and industrial development in Uzbekistan regarding the cultivation of lavender and the production of natural therapeutic products
Ascertaining The Factors Determining Brain Drain Among Final Year Medical Students And House Officers In Tertiary Institutions In South-South Nigeria
Brain drain (BD) is the movement of healthcare professionals from a country of poor standard of living to a country with high or better of living. In Nigeria, brain drain among healthcare professionals is on the increase and this is affecting the healthcare sector by creating a vacuum or caused shortage of manpower in the sector. Barin drain is an important issue that the government must give attention to the determining factors in order to curtail future occurrence. The aim of this study is Ascertaining Factors Determining Brain Drain Among Final Year Medical Students and House Officer in Tertiary Institutions in South-South Nigeria. This was a cross-sectional study involving 350 (final year medical students 200 and house officers 150). A well-structured questionnaire was administered to participants. The study lasted for a period of 2 months. Exclusion criteria were those medical students who were not in final year and doctors that were not house officers. Inclusion criteria were final medical students and house officers. This study used a simple random sample of 200 participants, calculated using the Taro Yamane formula, and data were analyzed with SPSS version 25.0. The results of the study shows that 57.1% were final year students while 42.9% were medical officers The study revealed that 71.4% of the House Officers do not enjoy their profession and 85.7% are planning to leave the country, 71.4% said working environment favourable, 80.0% have bad working relationship with your consultants, 85.7% said no automatic job and 71.4% find difficult in passing primaries. The research shows that 85.7% of the final medical students faced tough academic environment.
Using Bionic Architecture In Uzbekistan's Climate
This article explains the importance and application of bionic architecture in the climatic conditions of Uzbekistan. The arid and continental climate of Uzbekistan reveals the urgency of saving energy resources, ecological sustainability, and efficient use of natural resources. Recommendations are given that the use of bionic architecture is another direction that is suitable for the environment of Uzbekistan. It is noted that bionic architecture has been widely used in world practice and has achieved good results. The advantages of applying bionics to the architecture of Uzbekistan in the near future are highlighted.
Use Of Special Exercises In Developing The Strength Of Wrestlers
This article discusses the effective organization of the training process through the effective use of special tools to improve the physical, technical-tactical and psychological preparation of wrestlers, and to develop the quality of strength.
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