Eurasian Medical Research Periodical (EMRP) is an Open Access, Peer Reviewed, International, Refereed, Scientific Journal that publishes original research and review articles related to diverse areas of Medical Research Advancements etc. The main objective of Eurasian Medical Research Periodical (EMRP) is to offer an intellectual platform to the international scholars and it aims to promote interdisciplinary studies in Medical field. All manuscripts must be prepared in English language and subject to a rigorous peer-review process. The scope of the journal is not limited to Bioethics, Chronic non-communicable diseases (NCDs), Climate change, Deafness and other communication disorders, Eye disease, vision health and blindness, Global health security, Household air pollution., Implementation science etc. ISSN (E): 2795-7624 Journal Impact Factor: 8.120
Minimally Invasive Endoscopic Surgery for Chronic Diseases of the Maxillary Sinuses
Inflammatory diseases of the mucous membranes of the nasal cavity and paranasal sinuses remain one of the most common pathologies within the spectrum of ENT disorders; among these, lesions of the maxillary sinuses constitute the largest proportion of sinusitis cases. Their high prevalence, tendency toward a chronic and recurrent course, as well as the limited efficacy of traditional treatment methods, underscore the necessity of refining surgical approaches. The aim of this study was to optimize the surgical management of patients with chronic inflammatory diseases of the maxillary sinuses through the implementation of a minimally invasive endoscopic technique. The study involved 101 patients (45 women and 56 men) aged 15 to 75 years. Maxillary sinus cysts were diagnosed in 37 patients; fungal lesions (mycetomas) in 16; polyposis in 37; and chronic purulent sinusitis in 11 patients. All patients underwent an endoscopic procedure performed via a mini-access approach using a Kozlov trocar. The developed technique enabled comprehensive visualization of all compartments of the sinus and the radical removal of pathological formations (cysts, polyps, fungal masses, and foreign bodies) under endoscopic guidance, while ensuring minimal tissue trauma. The application of minimally invasive surgical principles contributed to reduced rehabilitation times and a lower risk of postoperative complications
Copyright (c) 2026 https://creativecommons.org/licenses/by-nc/4.0
Cardia Insufficiency as a Component of Gastroesophageal Reflux Disease and a Factor in Esophageal Carcinogenesis
Gastroesophageal reflux disease (GERD) is among the most common gastrointestinal disorders and represents an important risk factor for esophageal adenocarcinoma [4,8]. Dysfunction of the lower esophageal sphincter (cardia insufficiency) plays a central role in its development. Long-term exposure of the esophageal mucosa to gastric acid and bile acids leads to chronic inflammation, oxidative stress, and accumulation of genetic alterations, which may ultimately result in malignant transformation [7,12]. This paper reviews current data on the sequence of morphological changes, molecular mechanisms of carcinogenesis, and clinical implications for surveillance
Chondrosarcoma of the larynx is a rare type of laryngeal tumor that is often underestimated by patients and diagnosed at late stages of the disease. Clinical, histological, and radiological correlation is necessary for the diagnosis of chondrosarcoma of the larynx. Although the prognosis is relatively favorable, conservative surgical excision with negative margins is recommended. This article describes a case of chondrosarcoma of the larynx in a patient who required total laryngectomy.
Preventive Analysis of Anemia Developing Under the Influence of Environmental Factors (Case Study: The Aral Sea Region)
The desiccation of the Aral Sea and the prolonged impact of the resulting ecological crisis have created adverse conditions for the health of the population in the Aral Sea region. One of the most widespread consequences of this environmental degradation is irondeficiency anemia, particularly among women of reproductive age, pregnant women, nursing mothers, and children. Iron deficiency diminishes the blood's oxygen-carrying capacity, leads to tissue hypoxia, reduces physical and mental performance, and increases the risk of pregnancy complications as well as delays in physical and cognitive development in children. An analysis of epidemiological data (2020–2023) reveals that the prevalence of iron-deficiency anemia among pregnant women in the Aral Sea region reaches 45–50%, while among children under the age of five, it stands at 35–40%. These figures underscore the close correlation between environmental degradation and disturbances in trace element metabolism within the body. Under these conditions, anemia prevention must be approached as a comprehensive strategy encompassing improvements in drinking water quality and nutrition, the fortification of food products with iron and other trace elements, and the enhancement of public health and hygiene awareness among the population. The implementation of these measures will serve to reduce the prevalence of anemia and improve the overall health status of the residents of the Aral Sea region.
Molecular-Genetic Profiling As A Tool For Personalized Surgical Strategy In Acute Calculous Cholecystitis: A ProspectiveRetrospective Cohort Study
Acute calculous cholecystitis (ACC) is the second most common surgical emergency of the abdominal cavity. Despite advances in laparoscopic technique, the rate of destructive forms and associated complications remains substantial, largely because decisions regarding operative timing rely on subjective clinical criteria. Genetic polymorphisms governing inflammatory response, angiogenesis, and antioxidant defence may predetermine individual susceptibility to rapid gallbladder wall destruction; however, their clinical significance in the Uzbek ethnic population of the Fergana Valley has not previously been investigated.
Candidate Gene Polymorphisms As Predictors Of Severe Acute Pancreatitis And Adverse Surgical Outcomes: A Prospective Study In The Uzbek Population
Severe acute pancreatitis (SAP) carries a mortality of up to 40% and its clinical trajectory is only partially explained by conventional scoring systems. Genetic variation in pathways governing vascular response, tissue remodelling, oxidative stress, protease inhibition and drug metabolism may determine individual susceptibility to pancreatic necrosis. The present study aimed to quantify the prognostic contribution of five candidate single-nucleotide polymorphisms (SNPs) - VEGFA G634C (rs2010963), MMP9 Gln279Arg (rs17576), CAT C262T (rs1001179), CYP2C19*2 G681A (rs4244285) and SPINK1 Asn34Ser (rs17107315) - to the development of SAP, infectious complications and adverse surgical outcomes in an ethnically homogeneous Uzbek cohort.
SOD2 Gene Polymorphism (Ala16Val, rs4880) as a Predictor of Liver Cirrhosis in Chronic Hepatitis C: The Role of Oxidative Stress in Fibrosis Progression
Oxidative stress is a universal mechanism of hepatocyte damage in chronic hepatitis C (CHC). Manganese superoxide dismutase (SOD2) is the key mitochondrial antioxidant enzyme. The Ala16Val polymorphism (rs4880) affects enzyme import into the mitochondrial matrix. This study aimed to evaluate the association of SOD2 Ala16Val with liver cirrhosis (LC) formation in CHC patients and to assess its relationship with disease severity markers and esophageal varices (EV)
Complications After Surgical Treatment Of Anomalous Pulmonary Venous Connection
Anomalous pulmonary venous connection (APVC) is a congenital heart defect in which one or more pulmonary veins drain into the right atrium or systemic veins instead of the left atrium. This results in oxygenated blood returning to the right heart chambers, where it mixes with deoxygenated venous blood. Without timely surgical intervention, APVC leads to chronic hypoxia and progressive heart failure, affecting the child’s development and survival. Despite successful surgical correction, certain complications may arise in the postoperative period, requiring prompt attention. Literature analysis indicates that studying the outcomes and complications of APVC correction remains a highly relevant clinical issue. The aim of this study was to conduct a comparative evaluation of surgical outcomes for APVC correction depending on the type of defect and to identify the causes of mortality in the early postoperative period
Comparative Assessment Of Leptin And Adiponectin Dynamics Following Different Bariatric Procedures
This research focuses on evaluating changes in leptin and adiponectin concentrations in individuals undergoing bariatric surgery. These adipocytokines, which regulate fat metabolism and contribute to the progression of obesity, are key elements in its pathophysiology. The study enrolled 44 patients treated at the Endocrinology Department of TMA and Medion Family Hospital between 2022 and 2024. Participants were allocated into two cohorts: those who underwent gastric bypass (n = 19) and those who received sleeve gastrectomy (n = 25). Prior to and following the surgical intervention, biochemical indicators, hormonal profiles, and lipid metabolism parameters were analyzed. Twenty-four months post-operation, patients demonstrated a marked reduction in leptin and a notable rise in adiponectin, underscoring the positive metabolic impact of bariatric procedures in individuals with obesity
Vascular Remodeling And Endothelial Dysfunction After Experimental Splenectomy
To investigate morphofunctional changes in blood vessels after splenectomy in an experimental model. Materials and Methods: The experiment was conducted on adult white male rats divided into a control group and two experimental groups examined on days 14 and 30 after splenectomy. Histological and morphometric methods were applied to assess endothelial integrity, vascular wall structure, and microcirculatory parameters. Results: Splenectomy resulted in endothelial dysfunction, arterial wall remodeling, and significant microcirculatory disturbances. Early changes were predominantly compensatory-adaptive, whereas later stages were characterized by persistent structural alterations, capillary rarefaction, and signs of chronic tissue hypoxia.
Assessment Of Changes In Laboratory Indicators After Treatment In Patients Undergoing Hemodyalysis
The article presents a comparative study of laboratory indicators in patients undergoing hemodialysis following complex treatment procedures. The results demonstrate that during renal replacement therapy, patients continue to experience deficiencies in hemoglobin, albumin, calcium, and vitamin D. Conversely, the study shows persistently elevated levels of leukocytes, urea, creatinine, parathyroid hormone, and fibroblast growth factor-23 in the blood serum. These findings emphasize the necessity of an individualized approach to addressing these issues for each patient.
Improvement Of Trearment Methods For Hypertrophic Gingivitis In Patients With Epilepsy
Patients with epilepsy often demonstrate specific oral and periodontal changes associated with antiepileptic drug therapy, particularly gingival hyperthrophy. To evaluate the dental and periodontal status of patients with epilepsy and to substantiate improved approaches to the treatment of hypertrophic gingivitis in this group. Epilepsy and long-term antiepileptic therapy significantly affect periodontal tissues. Improved preventive and therapeutic approaches aimed at early diagnosis and conservative periodontal treatment are required to prevent tooth loss in epileptic patients
Challenges and limitations of AI systems in medical decisionmaking:Implications for trust, reliability, and clinical practice
Artificial Intelligence (AI) systems are increasingly used to support medical decisionmaking; however, their reliability in real-world clinical settings remains constrained by several fundamental limitations. While AI models often perform well in controlled research environments, their application in high-stakes clinical decisions raises concerns related to data quality, model confidence, and transparency. Clinical datasets are frequently biased, incomplete, or context-specific, which limits the generalizability of AIdriven recommendations across diverse patient populations. In addition, many AI systems present predictions with high confidence while failing to communicate uncertainty, increasing the risk of automation bias and overreliance in clinical practice. The lack of explainability in advanced AI models further complicates trust, accountability, and effective human–AI collaboration. This paper examines the key challenges and limitations of AI systems in medical decision-making, focusing on data-related constraints, model overconfidence, and explainability. It argues that the safe integration of AI into clinical practice requires trustworthy, uncertainty-aware, and human-centered decision-support systems rather than purely accuracy-driven models
Factors Affecting Survival In Patients Undergoing Hemodialysis
The article examines how age, gender, and several biochemical parameters affect survival to varying degrees in patients undergoing hemodialysis. The results indicate that a number of clinical and demographic factors have a significant negative impact on patient survival. It was found that for every 10-year increase in age, the risk of death rises by 1.61 times, demonstrating a significantly lower survival rate in elderly patients. The 28% higher risk of death in men compared to women is attributed to the higher prevalence of cardiovascular diseases among men. The presence of diabetes mellitus was found to nearly double the risk of death, and in hemodialysis patients, this disease was identified as an independent unfavorable prognostic factor. Chronic heart failure was determined to increase the risk of death by 2.5 times, making it one of the strongest negative factors among those analyzed.
Identification Of Morphological Changes In The Differentiation Processes Occurring In The Ovary In The Early Postpartum Period
This article is devoted to the identification of morphological changes that occur in the histotopography of the ovaries in girls in the early postpartum period. As a material, the ovaries of girls whose abdomen died of asphyxia and pneumopathy were studied using methods of general histology, histochemistry and morphometry. It was noticed that in the cortical layer of the ovary of newborns, rudimentary eggs are located in a dense state, follicular structures are formed as a result of the proliferation of granulose cells in the areas bordering the stratum corneum, and between them, i.e. in the interstitium, there are pregranular and celemic cells of different densities. It was found that by the age of 3 months in infants, the primary eggs in the ovarian mucosa are thinning, most of them undergo degenerative and destructive changes, bundles of fibrous connective tissue are formed in the intermediate tissue. From the earliest postpartum period, infants experience destruction and atresia of a part of the embryonic eggs that perform a reproductive function in the ovary, granulosis and proliferation of cells of the uterine tissue in the intermediate tissue
Integration of Artificial Intelligence and Modern Medicine
This academic article deeply analyzes the integration of artificial intelligence (AI) and modern medicine. It examines AI's main applications in diagnostics, drug discovery, and personalized medicine. The advantages of this integration for healthcare systems, such as increased efficiency, accuracy, and new opportunities, are thoroughly discussed. Concurrently, key challenges and limitations, including data management, ethical dilemmas, and regulatory constraints, are critically explored. Finally, the future prospects of AI in medicine, development trends, and recommendations for ensuring the safe, equitable, and effective integration of this transformative technology are presented
Melphalan-associated enteropathy in recipients of allogeneic hematopoietic stem cell transplantation: analysis of our own data and a literature review
The widespread use of high-dose melphalan in conditioning regimens for allogeneic hematopoietic stem cell transplantation (allo-HSCT) has led to an increased incidence of melphalan-associated enteropathy (MAE), a severe toxic intestinal injury. A key challenge in management is its differentiation from acute graft-versus-host disease (GVHD)
Topographic And Anatomical Pathways Of Tumor Dissemination In The Female Reproductive Organs
The anatomy of the female pelvis and reproductive organs constitutes a highly complex topographic–anatomical system that plays a pivotal role in understanding the clinical behavior and dissemination patterns of malignant tumors. Accurate knowledge of pelvic anatomy is of particular importance in gynecologic oncology, where surgical strategy, the extent of lymphadenectomy, identification of metastatic routes, and prognostic assessment are directly influenced by individual variations in vascular supply, lymphatic drainage, organ syntopy, and fascial and cellular compartments.
Copyright (c) 2025 https://creativecommons.org/licenses/by-nc/4.0
Evaluation of the Effectiveness of Immunotherapy in Combination with Conventional Treatment Modalities in Early-Stage Breast Cancer
Breast cancer remains the most frequently diagnosed malignant disease among women worldwide and continues to represent a major cause of cancer-related morbidity and mortality. Despite significant advances in screening, early detection, and multidisciplinary treatment, breast cancer poses ongoing clinical challenges due to its biological heterogeneity and variable response to therapy. Early-stage breast cancer, generally defined as stages I–II according to the TNM classification, is associated with favorable survival outcomes; however, a proportion of patients still experience disease recurrence, progression, or treatment-related toxicity
Analysis Of The Effectiveness Of Total Neoadjuvant Therapy In The Treatment Of Patients With Pancreatic Cancer
Pancreatic cancer remains one of the most aggressive and lethal malignancies in modern oncology and continues to pose a major clinical challenge worldwide. Pancreatic ductal adenocarcinoma (PDAC) accounts for more than 90% of all pancreatic malignancies and is characterized by rapid disease progression, early metastatic spread, and resistance to many conventional treatment modalities. Despite representing a smaller proportion of overall cancer incidence, pancreatic cancer ranks among the leading causes of cancer-related mortality, with five-year survival rates remaining below 15% in most populations. This unfavorable prognosis reflects a combination of late diagnosis, complex tumor biology, and limited therapeutic effectiveness
Akhmadzhanov Elmurodjon Burkhanidinovich
Radiological Approaches to Improve Detection of Delayed Hip Joint Complications in Post-COVID Patients
The objective of this study is to improve the diagnostic effectiveness of radiological methods in identifying late-stage post-COVID pathologies of the hip joint. This includes defining specific radiological features and patterns that characterize these complications, thereby aiding in early detection, accurate staging, and appropriate management of postCOVID hip joint diseases. Timely and precise diagnosis is essential to prevent progression to severe joint damage and reduce the risk of disability.
Optimizing Acute Pyelonephritis Diagnosis through Doppler Ultrasound Imaging
This article describes the way of improving the diagnosis of cute pyelonephritis, which is a bacterial infection of the renal pelvis and parenchyma most commonly seen in young women. It remains common and continues to have significant morbidity in certain groups of patients, using doppleroghraphy.
Ultrasound-Based Assessment in the Diagnosis of Hydronephrosis
Hydronephrosis refers to an abnormal enlargement of the renal pelvicalyceal system resulting from obstruction or disturbance of normal urinary drainage. This condition may present in either acute or chronic forms and, if not identified and managed promptly, can progress to permanent renal impairment and eventual kidney failure. Ultrasonography is widely recognized as the primary imaging technique for assessing hydronephrosis due to its broad accessibility, noninvasive nature, affordability, and absence of ionizing radiation. The aim of the present study is to evaluate the clinical significance and diagnostic effectiveness of ultrasound in the identification, differentiation, and follow-up of hydronephrosis across various underlying causes
A Critical Analysis Of The Phases Of Anesthesia In An Organized Health Care System
Anesthesia is a cornerstone of modern surgical practice, enabling pain-free and safe operative procedures. This paper presents a critical analysis of the phases of anesthesia within an organized health care system, emphasizing their clinical significance, safety considerations, and interprofessional coordination. The phases of anesthesia preoperative assessment, induction, maintenance, and recovery are examined in relation to standardized protocols, patient safety measures, and quality assurance frameworks. The study highlights the role of structured health care systems in optimizing anesthetic outcomes through effective communication, evidence-based practice, and continuous monitoring. Challenges such as patient variability, resource limitations, and perioperative risks are critically evaluated, alongside strategies for improvement including adherence to guidelines, technological advancements, and workforce training. By analyzing anesthesia care across its phases, the study concluded that the phases of anesthesia preoperative assessment, induction, maintenance, and recovery are interdependent components of safe and effective anesthetic care. This critical analysis demonstrates that the success of anesthesia management is largely influenced by the level of organization within the health care system. An organized health care structure supports standardized protocols, skilled personnel, and effective. One of the recommendations made was that, Health care institutions should prioritize comprehensive preoperative evaluations to identify risk factors, optimize patient conditions, and plan individualized anesthetic care.
Modern Aspects Of Etiology, Pathogenesis, Diagnosis And Treatment Of Chronic Generalized Periodontitis
Chronic Generalized periodontitis is one of the most common inflammatory and destructive pathologies of periodontal tissues and is a leading cause of premature tooth loss in adults. The disease is characterized by a multifactorial etiology, complex pathogenesis, and a close relationship with general somatic pathology. This article presents an analysis of current data on the etiological factors and pathogenetic mechanisms of the development of chronic generalized periodontitis. The clinical manifestations of the disease depending on the severity, modern diagnostic methods, including clinical, radiological, and laboratory approaches are considered. Particular attention is paid to the principles of comprehensive treatment, including conservative, surgical, and preventive measures aimed at stabilizing the pathological process and preventing relapse. The need for an individualized and interdisciplinary approach to the management of patients with chronic periodontitis is demonstrated. generalized periodontitis.
Bees Poison And His Joint In Diseases Effect
This article joint diseases in treatment bees healing of poison ( apitoxin ). effect him to the joints and to the organism effect effect will be lit. Bees by calling treatment the main type of treatment methods advantages is displayed .
Diastolic Dysfunction of the Left and Right Ventricles in Patients with Ischemic Heart Disease at the Early Stages of Chronic Heart Failure
The concept of “diastolic dysfunction” is based on both structural and functional remodeling of cardiomyocytes and the interstitial matrix, leading to increased myocardial stiffness [2,4]. Unlike systole, during which Ca²⁺ ions are actively released from the sarcoplasmic reticulum into the cytosol, myocardial relaxation is an energy-dependent process associated with the active transport of Ca²⁺ ions back into the sarcoplasmic reticulum against a concentration gradient [10]. This mechanism explains why disturbances in myocardial relaxation occur earlier than systolic dysfunction, particularly under conditions of myocardial ischemia in ischemic heart disease (IHD) [3,6,9]. The mechanisms underlying impaired diastolic function in IHD can be conventionally divided into two categories: disorders of active relaxation caused by the development of cardiosclerosis and those associated with myocardial ischemia
A Clinical Study Of The Method Of Early Diagnosis Of Coronary Heart Disease
Recently, the issue of early diagnosis of coronary heart disease (CHD) remains the most urgent task of cardiology. The gas analytical method for the analysis of exhaled air (EA) is a new approach to solving this problem [1,5,11]. Our clinical studies of this technique, used to develop a non-invasive method for the diagnosis of coronary heart disease, have led to the following main results: CHD is accompanied by impaired metabolism of biogenic amines [6], volatile biogenic amines are found in the composition of explosives in patients with CHD [1, 2], the content of diethylamine in explosives increases most significantly in patients with postinfarction cardiosclerosis (PICS) [7], secondary amines (SA) can be formed as a result of the reduction of Schiff bases (SHO) under acidosis conditions in the cellular sarcosomes of the cardiac muscle [8,9]. However, the nature of the dependence of the kinetic parameters of SA formation on the degree and scale of ischemic myocardial zones remains unclear.
Osteocalcin As A Marker Of Bone Metabolism Disorders In Children With Juvenile Idiopathic Arthritis
To determine the relationship between osteocalcin and markers of inflammation and bone metabolism in children with juvenile idiopathic arthritis (JIA).
Tumors Of The Head And Neck: Detection At Stage T Using Modern Imaging Techniques
Tumors of the head and neck are characterized by an aggressive course and a high risk of late diagnosis. Despite advances in oncology, most patients are admitted to specialized centers at stages T2–T4, when the effectiveness of treatment is significantly reduced. The detection of tumors at the T₀ stage, when there are no clinical manifestations yet, but morphological and metabolic changes are already forming, is a key area of modern oncorentgenology . The article discusses the possibilities of magnetic resonance imaging (MRI), computed tomography (CT) and positron emission tomography (PET/CT) in the diagnosis of head and neck tumors in the early stages. The results of clinical observations are presented, showing that the use of multiparametric MRI and hybrid technologies can increase the detectability of subclinical forms up to 92%.