Eurasian Medical Research Periodical (EMRP) is an Open Access, Peer Reviewed, International, Refereed, Scientific Journal that publishes original research and review articles related to diverse areas of Medical Research Advancements etc. The main objective of Eurasian Medical Research Periodical (EMRP) is to offer an intellectual platform to the international scholars and it aims to promote interdisciplinary studies in Medical field. All manuscripts must be prepared in English language and subject to a rigorous peer-review process. The scope of the journal is not limited to Bioethics, Chronic non-communicable diseases (NCDs), Climate change, Deafness and other communication disorders, Eye disease, vision health and blindness, Global health security, Household air pollution., Implementation science etc. ISSN (E): 2795-7624 Journal Impact Factor: 8.120
A clinical case of Fisher-Evans syndrome
SFE is a fairly rare disease. In cases where SFE presents with isolated ITP, and the second cytopenia develops after several months or even years, it is impossible to establish a diagnosis immediately. The described patient developed AIGA and ITP at the same time. It is also necessary to remember the importance of determining the Coombs test during the initial diagnosis of ITP and further during patient follow–up, and in patients with ITP and AIG, the basal level of serum immunoglobulins to detect PID. In all cases of SFE, it is necessary to conduct an additional examination using molecular genetic methods in order to find a possible cause of the development of secondary SFE. After the therapy, there is a positive trend in clinical signs and laboratory test results. Taking into account that the prognosis for immune cytopenia in the framework of SFE is quite unfavorable, long-term combined IST is usually recommended. Thus, the above clinical case demonstrates the positive effect ofthe treatment. Taking into account the literature data on the recurrence of the disease, dynamic monitoring of the patient's condition and laboratory tests is necessary
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Pathophysiology Of Pulmonary And Systemic Hemodynamics In Chronic Obstructive Pulmonary Disease
This scientific review systematizes and analyzes current evidence regarding the mechanisms underlying pulmonary and systemic hemodynamic disturbances in patients with chronic obstructive pulmonary disease (COPD). The cardiopulmonary continuum is examined, within which chronic hypoxia, systemic inflammation (the “spill-over” phenomenon of cytokines such as IL-6, TNF-α, and C-reactive protein [CRP]), and oxidative stress initiate a cascade of pathological changes ranging from hypoxic pulmonary vasoconstriction to structural remodeling of the pulmonary vasculature, generalized endothelial dysfunction, and anatomical reduction of the pulmonary capillary network associated with emphysema. The review provides a detailed description of the pathophysiological mechanisms involved in the development of cor pulmonale, left ventricular diastolic dysfunction resulting from interventricular interaction and fluctuations in intrathoracic pressure, as well as the formation of an arrhythmogenic substrate. A critical analysis is presented of contemporary diagnostic approaches, including echocardiography, computed tomography pulmonary angiography (CTPA), cardiac magnetic resonance imaging (MRI), biomarkers such as N-terminal pro-B-type natriuretic peptide (NT-proBNP), and current therapeutic strategies, with particular emphasis on the limitations of pulmonary hypertension-specific therapies in COPD patients. The authors highlight the necessity of transitioning toward precision medicine through the identification of the vascular phenotype of COPD and the integration of artificial intelligence and radiomics technologies for the early subclinical detection of hemodynamic abnormalities.
Vertebral Artery Syndrome: Literature Review With A Focus On Etiology, Classification, Diagnosis, And Treatment
Vertebral artery syndrome (VAS) is a relevant interdisciplinary problem in modern neurology caused by impaired blood flow in the vertebral arteries and their branches. The review examines current concepts of the epidemiology, risk factors, and pathogenesis of VAS, with special attention paid to its association with cervical spondylosis and lifestyle. The main classifications (etiopathogenetic, clinical, topical, by stages and mechanisms), clinical variants of the course, diagnostic criteria according to N.V. Vereshchagin, as well as the algorithm of complex examination are presented. The principles of conservative and surgical treatment, rehabilitation, and prevention are highlighted. The necessity of early diagnosis, a differential approach, and interdisciplinary interaction to improve outcomes and quality of life of patients is emphasized.
Features Of The Clinical Current Of Scalls In The Modern Stage
Measles is a highly contagious disease of viral etiology. To this day, the measles remains one of the main causes of death in younger age groups, even despite many years of positive experience in using an effective live measles vaccine. With the ongoing complication of the epidemiological situation regarding the measles, both in the country and globally, it seems appropriate to study the immune layer to the measles virus in various gender, age, and social groups and to identify risk groups most susceptible to infection. According to our observations, in most cases, 94.4% of cases of measles proceeded in a typical moderate form. The typical moderate form of measles was characterized by a cyclical course with a change in classical periods, the presence of characteristic clinical syndromes of the disease. Pathognomonic symptoms for measles were identified: Belskiy-Filatov-Koplik spots (67.7%), staged eruption (100%), staged pigmentation (100%). Modern comprehensive therapy of young children with measles in combination with antioxidants (vitamins C and E) has significantly reduced the severity of complications, the frequency of the uneven course of the disease, and prevented the spread of acute respiratory viral infections
Breast Cancer And Bone Metastasis: A Critical Analysis of Traditional and Modern Treatment Strategies
Breast cancer represents one of the most prevalent malignancies worldwide, with bone metastasis occurring in approximately 65–75% of patients with advanced-stage disease. The colonisation of the skeletal system by tumour cells precipitates a debilitating cycle of osteolytic and osteoblastic destruction, significantly compromising patient survival, functional capacity, and quality of life. This review critically analyses and compares the therapeutic landscape governing breast cancer–related bone metastasis, from established modalities—including chemotherapy, endocrine therapy, and external beam radiotherapy—to contemporary advances in targeted therapy, bone-modifying agents, immunotherapy, and precision medicine.
Abdivokhobova Gulnozakhon Shuhratbek kizi
Parasitic Infections: Etiology, Epidemiology, Pathogenesis, and Diagnosis
Parasitic infections are diseases caused by protozoa, helminths, and ectoparasites that can affect the internal organs, blood, nervous system, and skin of the human body. [1] These infections remain a significant public health concern worldwide, particularly in developing countries. [1,10] This article provides a scientific review of their etiology, global epidemiology, pathogenesis, clinical manifestations, diagnostic approaches, treatment, and prevention strategies. Special attention is given to modern laboratory, serological, and molecular diagnostic methods, including Polymerase Chain Reaction (PCR) and Enzyme-Linked Immunosorbent Assay (ELISA)
This paper examines the problem of the development of leukosis, or blood cancer, in children, which accounts for a significant proportion of all pediatric oncological diseases. In Uzbekistan, leukosis and other oncohematological diseases are considered serious and pressing issues and require special attention from the healthcare system. The paper reviews the main causes of this pathology, including mutations and disruptions of hematopoiesis in the bone marrow due to genetic predisposition, exposure to chemical carcinogens, viruses and radiation. The article also briefly presents current data on the prevalence of leukosis both in Uzbekistan and globally, allowing an assessment of the scale of the problem.
Distribution And Clinical Significance of Microdeletions in The AZF Region of The Y Chromosome in Male Infertility
This article examines various types of microdeletions in the AZF region of the Y chromosome and their impact on male infertility. Particular attention is given to the prevalence of AZF microdeletions among patients with azoospermia and oligozoospermia, as well as their clinical manifestations. Data are presented on the prevalence of AZFa, AZFb, and AZFc microdeletions and their effects on male reproductive function. The primary focus is on the pathogenesis, molecular mechanisms, and diagnosis of these abnormalities. For each type of microdeletion, clinical features, diagnostic methods, and treatment approaches using assisted reproductive technologies are described
Diagnostic Significance Of Predictive Biomarkers In Forecasting The Development Of Autoimmune Hepatitis
This study investigated the diagnostic and prognostic significance of immunological panels and non-invasive biochemical indices in predicting the development of autoimmune hepatitis (AIH) in patients with autoimmune hemolytic anemia (AIHA). The prognostic potential of Liver-9-Line immunological systems, as well as APRI, FIB-4, King’s score, and the De Ritis index, was evaluated at the early and late stages of the disease. The analysis demonstrated that immunological panels possess higher diagnostic and prognostic efficiency compared to conventional indices. In particular, Liver-9-Line and Liver-3-Line were identified as the most reliable markers for the early detection of AIH development. The obtained results confirm that immunological profiling plays an important role in the early identification and monitoring of patients belonging to highrisk groups.
Prevention Of Reflux Esophagitis After Gastrectomy
Reflux esophagitis is one of the most common and clinically significant complications after gastrectomy. Its development is associated with the loss of the reservoir and barrier functions of the stomach, disruption of anatomical and physiological antireflux mechanisms, and altered gastrointestinal motility. This condition significantly reduces patients’ quality of life and may lead to erosive and ulcerative lesions of the esophagus. The article discusses modern approaches to the prevention of reflux esophagitis after gastrectomy, including surgical, pharmacological, and dietary methods. Special attention is given to reconstructive surgical techniques aimed at reducing duodenogastroesophageal reflux
The Gap Between Prevalence and Awareness in Autoimmune Thyroid Diseases: A Systematic Synthesis and MetaAnalysis
Autoimmune thyroid diseases (AITD), primarily comprising Hashimoto’s thyroiditis (HT) and Graves’ disease (GD), represent the most prevalent group of autoimmune disorders globally, affecting approximately 5% of the general population (Hu et al., 2022). The pathogenesis of AITD involves a complex interplay between genetic susceptibility, environmental triggers, and immune dysregulation, leading to the production of thyroidspecific autoantibodies such as anti-thyroid peroxidase (TPOAb) and anti-thyroglobulin (TgAb). Over the last decade, epidemiological shifts have been observed, with a steady increase in the incidence of AITD in both iodine-sufficient and formerly iodine-deficient regions. While the implementation of Universal Salt Iodization (USI) programs has been a cornerstone of global public health, reducing the prevalence of endemic goiter, it has paradoxically been associated with a rise in thyroid autoimmunity (Botello et al., 2020). This phenomenon necessitates a transition in public health focus: from basic iodine deficiency to the more nuanced management of chronic autoimmune inflammation.
Influence Of Diabetes Mellitus And Cognitive Status On The Progression Of Age-Related Cataract: A Retrospective Clinical-Statistical Study
This article presents a detailed retrospective analysis of comorbidity in patients with age-related cataract. The study covers clinical data from 30 patients, including ophthalmological status, presence of diabetes mellitus, and cognitive function indices. Using variation statistics methods (Student’s t-test), the significant influence of hyperglycemia on accelerating the rate of lens degradation was demonstrated. A correlation between visual impairment and reduced cognitive reserve according to MMSE and MoCA scales was identified.
Early Perinatal Screening System In Central Asian Countries: Comparative Analysis Of Effectiveness, Coverage And Systemic Problems
Early perinatal screening is important for the timely detection of congenital malformations and improving maternal and child health. The purpose of this study is to conduct a comparative analysis of the effectiveness, coverage and systemic problems of the early perinatal screening system in Central Asian countries. The study analyzed secondary data based on data from international organizations, national health reports and scientific literature. Comparative analysis, statistical evaluation and a systematic approach were used as research methodologies. Screening coverage, the level of use of diagnostic technologies, the availability of qualified specialists, and the introduction of modern methods, including non-invasive prenatal testing (NIPT), were studied. The results showed that there are significant differences in the coverage and effectiveness of the perinatal screening system among the Central Asian countries. While some countries are experiencing positive changes as a result of reforms and technological innovations in the health system, in other regions limited financial resources, insufficiently developed medical infrastructure, and low awareness of the population were identified as the main problems. It was also noted that the level of integration of digital technologies and artificial intelligence into prenatal diagnostics varies across regions. Improving the early perinatal screening system in Central Asian countries requires an integrated approach. In this process, standardization of health policies, development of medical infrastructure, increasing human resources capacity, and raising awareness of the population are important.
The Nocebo Effect: The Impact of Negative Words and Beliefs on the Human Organism
The nocebo effect is a psychoneurobiological phenomenon in which negative expectations, beliefs, and verbal suggestions lead to measurable physiological and psychological changes in the human body. It is considered the inverse counterpart of the placebo effect, where instead of improvement through positive expectations, harm or worsening of symptoms occurs due to negative anticipation. The mechanism of the nocebo effect is closely related to cognitive appraisal and the brain’s stress-response systems. When a person is exposed to negative information—such as warnings about side effects, pessimistic predictions, or harmful labels—the brain activates stress-related pathways, including the hypothalamic-pituitary-adrenal (HPA) axis. This activation leads to increased cortisol release, heightened anxiety, and changes in pain perception
Optimization Of Intensive Care For Nephro- And Hepatotoxicity Of Lung Cancer Chemotherapy
Lung cancer remains the leading cause of cancer mortality worldwide, and systemic chemotherapy is a cornerstone of treatment for advanced stages. However, many chemotherapeutic agents used in lung cancer can cause significant nephrotoxicity and hepatotoxicity, which may limit therapy, necessitate dose reductions, or even lead to lifethreatening organ failure. Cisplatin-based regimens, for example, are highly effective but carry a well-documented risk of acute kidney injury (AKI) due to proximal tubular damage, electrolyte disturbances, and reduced glomerular filtration. Likewise, various cytotoxic drugs can induce liver injury in idiosyncratic patterns ranging from transient asymptomatic transaminase elevations to fulminant hepatic failure. Optimizing intensive care management of these toxicities is essential to ensure patients can safely continue potentially curative treatments. This narrative review summarizes the nephrotoxic and hepatotoxic effects of common lung cancer chemotherapeutic agents and discusses strategies to prevent and mitigate these toxicities
The Impact Of Diabetes Mellitus On The Course Of Interstitial Pneumonia In An Experimental Model And The Possibility Of Correcting The Detected Disorders
Given the growing recognition of the interplay between metabolic disorders and chronic lung diseases, this study aimed to assess, based on biochemical parameters of lung tissue, the effectiveness of vegetable oils in preventing interstitial lung lesions in rats with alloxan-induced diabetes and experimental interstitial pulmonary fibrosis.
Artificial Intelligence Technologies In Magnetic Resonance Imaging: A New Paradigm In Increasing Diagnostic Accuracy And Clinical Decision-Making
This article systematically analyzes the application of artificial intelligence (AI) and deep learning algorithms in magnetic resonance imaging (MRI) systems, their role in improving diagnostic accuracy, and their impact on the clinical decision-making process. The study evaluates the clinical effectiveness of AI-based automatic segmentation, pathology classification, and disease outcome prediction models. Special attention is given to the "black-box" problems of AI models, ensuring data privacy, and the concept of Explainable AI (XAI). Furthermore, the existing challenges and future prospects of implementing these innovative technologies into daily clinical practice are widely discussed.
Distinctive Clinical Features Of Patients With Systemic Sclerosis
Systemic sclerosis is a rare, chronic, multisystem autoimmune connective tissue disease in which microvascular injury, immune dysregulation, and progressive fibrosis combine to produce one of the most heterogeneous clinical phenotypes in modern rheumatology. The disease may begin insidiously with Raynaud’s phenomenon, puffy fingers, fatigue, reflux symptoms, or subtle nailfold capillary abnormalities long before a fully classifiable syndrome emerges, yet it can subsequently evolve into a condition marked by skin thickening, digital ischemia, gastrointestinal dysmotility, interstitial lung disease, pulmonary vascular disease, cardiac involvement, renal crisis, musculoskeletal dysfunction, and major impairment in quality of life and survival. The present narrative review aims to synthesize contemporary evidence on the distinctive clinical manifestations of systemic sclerosis, emphasizing the temporal evolution of symptoms, phenotype-based stratification, and the diagnostic significance of early vascular and cutaneous clues. Particular attention is given to the clinical contrast between limited cutaneous and diffuse cutaneous disease, the importance of systemic sclerosis-specific autoantibodies as markers of organ risk rather than mere laboratory labels, and the relevance of very early diagnosis frameworks in patients who present with Raynaud’s phenomenon before overt fibrosis develops. The review also examines the major organspecific manifestations that define disease burden, including esophageal dysfunction, malabsorption, pulmonary fibrosis, pulmonary arterial hypertension, myocarditis-like and arrhythmic phenotypes, and scleroderma renal crisis, together with overlap syndromes and systemic sclerosis sine scleroderma. By integrating classification criteria, cohort data, and recent guideline-based approaches to assessment, this paper argues that the clinical identity of systemic sclerosis is best understood not as a static syndrome but as a dynamic phenotype in which the sequence, clustering, and severity of manifestations determine prognosis and guide surveillance. Recognition of the disease’s characteristic clinical signatures—especially persistent Raynaud’s phenomenon with abnormal capillaroscopy, puffy fingers, digital lesions, telangiectasia, evolving sclerodactyly, early reflux, and unexplained dyspnea—remains central to reducing diagnostic delay and improving outcomes through earlier specialist referral and structured multiorgan screening
“Iron-Deficiency Anemia In Children And Adolescents In Uzbekistan”
This paper examines the issue of iron-deficiency anemia in children and adolescents, a condition that remains one of the most prevalent pathologies in our country today. Particular attention is focused on the current situation in Uzbekistan, where, despite ongoing preventive measures, the rate of iron deficiency remains notably high. The study analyzes the primary causes underlying the development of this condition, highlighting factors such as an unbalanced diet, increased physiological requirements during periods of growth, and the impact of chronic diseases and socioeconomic factors. Special consideration is given to the specific clinical characteristics of iron-deficiency anemia in adolescents, particularly in girls. Furthermore, the article briefly presents current data regarding the prevalence of anemia—both within Uzbekistan and globally—thereby providing a context for assessing the true scale of the problem. The paper underscores the impact of iron deficiency on the physical and cognitive development of children, as well as its role in diminishing their overall quality of life. The objective of this study is to investigate the prevalence, etiology, and risk factors associated with iron-deficiency anemia in children and adolescents, and to establish its significance as a critical public health concern.
Minimally Invasive Endoscopic Surgery for Chronic Diseases of the Maxillary Sinuses
Inflammatory diseases of the mucous membranes of the nasal cavity and paranasal sinuses remain one of the most common pathologies within the spectrum of ENT disorders; among these, lesions of the maxillary sinuses constitute the largest proportion of sinusitis cases. Their high prevalence, tendency toward a chronic and recurrent course, as well as the limited efficacy of traditional treatment methods, underscore the necessity of refining surgical approaches. The aim of this study was to optimize the surgical management of patients with chronic inflammatory diseases of the maxillary sinuses through the implementation of a minimally invasive endoscopic technique. The study involved 101 patients (45 women and 56 men) aged 15 to 75 years. Maxillary sinus cysts were diagnosed in 37 patients; fungal lesions (mycetomas) in 16; polyposis in 37; and chronic purulent sinusitis in 11 patients. All patients underwent an endoscopic procedure performed via a mini-access approach using a Kozlov trocar. The developed technique enabled comprehensive visualization of all compartments of the sinus and the radical removal of pathological formations (cysts, polyps, fungal masses, and foreign bodies) under endoscopic guidance, while ensuring minimal tissue trauma. The application of minimally invasive surgical principles contributed to reduced rehabilitation times and a lower risk of postoperative complications
Cardia Insufficiency as a Component of Gastroesophageal Reflux Disease and a Factor in Esophageal Carcinogenesis
Gastroesophageal reflux disease (GERD) is among the most common gastrointestinal disorders and represents an important risk factor for esophageal adenocarcinoma [4,8]. Dysfunction of the lower esophageal sphincter (cardia insufficiency) plays a central role in its development. Long-term exposure of the esophageal mucosa to gastric acid and bile acids leads to chronic inflammation, oxidative stress, and accumulation of genetic alterations, which may ultimately result in malignant transformation [7,12]. This paper reviews current data on the sequence of morphological changes, molecular mechanisms of carcinogenesis, and clinical implications for surveillance
Chondrosarcoma of the larynx is a rare type of laryngeal tumor that is often underestimated by patients and diagnosed at late stages of the disease. Clinical, histological, and radiological correlation is necessary for the diagnosis of chondrosarcoma of the larynx. Although the prognosis is relatively favorable, conservative surgical excision with negative margins is recommended. This article describes a case of chondrosarcoma of the larynx in a patient who required total laryngectomy.
Preventive Analysis of Anemia Developing Under the Influence of Environmental Factors (Case Study: The Aral Sea Region)
The desiccation of the Aral Sea and the prolonged impact of the resulting ecological crisis have created adverse conditions for the health of the population in the Aral Sea region. One of the most widespread consequences of this environmental degradation is irondeficiency anemia, particularly among women of reproductive age, pregnant women, nursing mothers, and children. Iron deficiency diminishes the blood's oxygen-carrying capacity, leads to tissue hypoxia, reduces physical and mental performance, and increases the risk of pregnancy complications as well as delays in physical and cognitive development in children. An analysis of epidemiological data (2020–2023) reveals that the prevalence of iron-deficiency anemia among pregnant women in the Aral Sea region reaches 45–50%, while among children under the age of five, it stands at 35–40%. These figures underscore the close correlation between environmental degradation and disturbances in trace element metabolism within the body. Under these conditions, anemia prevention must be approached as a comprehensive strategy encompassing improvements in drinking water quality and nutrition, the fortification of food products with iron and other trace elements, and the enhancement of public health and hygiene awareness among the population. The implementation of these measures will serve to reduce the prevalence of anemia and improve the overall health status of the residents of the Aral Sea region.
Molecular-Genetic Profiling As A Tool For Personalized Surgical Strategy In Acute Calculous Cholecystitis: A ProspectiveRetrospective Cohort Study
Acute calculous cholecystitis (ACC) is the second most common surgical emergency of the abdominal cavity. Despite advances in laparoscopic technique, the rate of destructive forms and associated complications remains substantial, largely because decisions regarding operative timing rely on subjective clinical criteria. Genetic polymorphisms governing inflammatory response, angiogenesis, and antioxidant defence may predetermine individual susceptibility to rapid gallbladder wall destruction; however, their clinical significance in the Uzbek ethnic population of the Fergana Valley has not previously been investigated.
Candidate Gene Polymorphisms As Predictors Of Severe Acute Pancreatitis And Adverse Surgical Outcomes: A Prospective Study In The Uzbek Population
Severe acute pancreatitis (SAP) carries a mortality of up to 40% and its clinical trajectory is only partially explained by conventional scoring systems. Genetic variation in pathways governing vascular response, tissue remodelling, oxidative stress, protease inhibition and drug metabolism may determine individual susceptibility to pancreatic necrosis. The present study aimed to quantify the prognostic contribution of five candidate single-nucleotide polymorphisms (SNPs) - VEGFA G634C (rs2010963), MMP9 Gln279Arg (rs17576), CAT C262T (rs1001179), CYP2C19*2 G681A (rs4244285) and SPINK1 Asn34Ser (rs17107315) - to the development of SAP, infectious complications and adverse surgical outcomes in an ethnically homogeneous Uzbek cohort.
SOD2 Gene Polymorphism (Ala16Val, rs4880) as a Predictor of Liver Cirrhosis in Chronic Hepatitis C: The Role of Oxidative Stress in Fibrosis Progression
Oxidative stress is a universal mechanism of hepatocyte damage in chronic hepatitis C (CHC). Manganese superoxide dismutase (SOD2) is the key mitochondrial antioxidant enzyme. The Ala16Val polymorphism (rs4880) affects enzyme import into the mitochondrial matrix. This study aimed to evaluate the association of SOD2 Ala16Val with liver cirrhosis (LC) formation in CHC patients and to assess its relationship with disease severity markers and esophageal varices (EV)
Complications After Surgical Treatment Of Anomalous Pulmonary Venous Connection
Anomalous pulmonary venous connection (APVC) is a congenital heart defect in which one or more pulmonary veins drain into the right atrium or systemic veins instead of the left atrium. This results in oxygenated blood returning to the right heart chambers, where it mixes with deoxygenated venous blood. Without timely surgical intervention, APVC leads to chronic hypoxia and progressive heart failure, affecting the child’s development and survival. Despite successful surgical correction, certain complications may arise in the postoperative period, requiring prompt attention. Literature analysis indicates that studying the outcomes and complications of APVC correction remains a highly relevant clinical issue. The aim of this study was to conduct a comparative evaluation of surgical outcomes for APVC correction depending on the type of defect and to identify the causes of mortality in the early postoperative period
Comparative Assessment Of Leptin And Adiponectin Dynamics Following Different Bariatric Procedures
This research focuses on evaluating changes in leptin and adiponectin concentrations in individuals undergoing bariatric surgery. These adipocytokines, which regulate fat metabolism and contribute to the progression of obesity, are key elements in its pathophysiology. The study enrolled 44 patients treated at the Endocrinology Department of TMA and Medion Family Hospital between 2022 and 2024. Participants were allocated into two cohorts: those who underwent gastric bypass (n = 19) and those who received sleeve gastrectomy (n = 25). Prior to and following the surgical intervention, biochemical indicators, hormonal profiles, and lipid metabolism parameters were analyzed. Twenty-four months post-operation, patients demonstrated a marked reduction in leptin and a notable rise in adiponectin, underscoring the positive metabolic impact of bariatric procedures in individuals with obesity
Vascular Remodeling And Endothelial Dysfunction After Experimental Splenectomy
To investigate morphofunctional changes in blood vessels after splenectomy in an experimental model. Materials and Methods: The experiment was conducted on adult white male rats divided into a control group and two experimental groups examined on days 14 and 30 after splenectomy. Histological and morphometric methods were applied to assess endothelial integrity, vascular wall structure, and microcirculatory parameters. Results: Splenectomy resulted in endothelial dysfunction, arterial wall remodeling, and significant microcirculatory disturbances. Early changes were predominantly compensatory-adaptive, whereas later stages were characterized by persistent structural alterations, capillary rarefaction, and signs of chronic tissue hypoxia.
Assessment Of Changes In Laboratory Indicators After Treatment In Patients Undergoing Hemodyalysis
The article presents a comparative study of laboratory indicators in patients undergoing hemodialysis following complex treatment procedures. The results demonstrate that during renal replacement therapy, patients continue to experience deficiencies in hemoglobin, albumin, calcium, and vitamin D. Conversely, the study shows persistently elevated levels of leukocytes, urea, creatinine, parathyroid hormone, and fibroblast growth factor-23 in the blood serum. These findings emphasize the necessity of an individualized approach to addressing these issues for each patient.