Eurasian Medical Research Periodical
type: channel
description: Eurasian Medical Research Periodical (EMRP) is an Open Access, Peer Reviewed, International, Refereed, Scientific Journal that publishes original research and review articles related to diverse areas of Medical Research Advancements etc. The main objective of Eurasian Medical Research Periodical (EMRP) is to offer an intellectual platform to the international scholars and it aims to promote interdisciplinary studies in Medical field. All manuscripts must be prepared in English language and subject to a rigorous peer-review process. The scope of the journal is not limited to Bioethics, Chronic non-communicable diseases (NCDs), Climate change, Deafness and other communication disorders, Eye disease, vision health and blindness, Global health security, Household air pollution., Implementation science etc. ISSN (E): 2795-7624 Journal Impact Factor: 8.120
publisher: Genius Journals
language: en
publication name: Eurasian Medical Research Periodical
issn: 2795-7624
items: Minimally Invasive Endoscopic Surgery for Chronic Diseases of the Maxillary Sinuses
items: Cardia Insufficiency as a Component of Gastroesophageal Reflux Disease and a Factor in Esophageal Carcinogenesis
items: Larengeal chondrosarcoma (case report)
items: Preventive Analysis of Anemia Developing Under the Influence of Environmental Factors (Case Study: The Aral Sea Region)
items: Molecular-Genetic Profiling As A Tool For Personalized Surgical Strategy In Acute Calculous Cholecystitis: A ProspectiveRetrospective Cohort Study
items: Candidate Gene Polymorphisms As Predictors Of Severe Acute Pancreatitis And Adverse Surgical Outcomes: A Prospective Study In The Uzbek Population
items: SOD2 Gene Polymorphism (Ala16Val, rs4880) as a Predictor of Liver Cirrhosis in Chronic Hepatitis C: The Role of Oxidative Stress in Fibrosis Progression
items: Complications After Surgical Treatment Of Anomalous Pulmonary Venous Connection
items: Comparative Assessment Of Leptin And Adiponectin Dynamics Following Different Bariatric Procedures
items: Vascular Remodeling And Endothelial Dysfunction After Experimental Splenectomy
items: Assessment Of Changes In Laboratory Indicators After Treatment In Patients Undergoing Hemodyalysis
items: Improvement Of Trearment Methods For Hypertrophic Gingivitis In Patients With Epilepsy
items: Challenges and limitations of AI systems in medical decisionmaking:Implications for trust, reliability, and clinical practice
items: Factors Affecting Survival In Patients Undergoing Hemodialysis
items: Identification Of Morphological Changes In The Differentiation Processes Occurring In The Ovary In The Early Postpartum Period
items: Integration of Artificial Intelligence and Modern Medicine
items: Melphalan-associated enteropathy in recipients of allogeneic hematopoietic stem cell transplantation: analysis of our own data and a literature review
items: Topographic And Anatomical Pathways Of Tumor Dissemination In The Female Reproductive Organs
items: Evaluation of the Effectiveness of Immunotherapy in Combination with Conventional Treatment Modalities in Early-Stage Breast Cancer
items: Analysis Of The Effectiveness Of Total Neoadjuvant Therapy In The Treatment Of Patients With Pancreatic Cancer
items: Radiological Approaches to Improve Detection of Delayed Hip Joint Complications in Post-COVID Patients
items: Optimizing Acute Pyelonephritis Diagnosis through Doppler Ultrasound Imaging
items: Ultrasound-Based Assessment in the Diagnosis of Hydronephrosis
items: A Critical Analysis Of The Phases Of Anesthesia In An Organized Health Care System
items: Modern Aspects Of Etiology, Pathogenesis, Diagnosis And Treatment Of Chronic Generalized Periodontitis
items: Bees Poison And His Joint In Diseases Effect
items: Diastolic Dysfunction of the Left and Right Ventricles in Patients with Ischemic Heart Disease at the Early Stages of Chronic Heart Failure
items: A Clinical Study Of The Method Of Early Diagnosis Of Coronary Heart Disease
items: Osteocalcin As A Marker Of Bone Metabolism Disorders In Children With Juvenile Idiopathic Arthritis
items: Tumors Of The Head And Neck: Detection At Stage T Using Modern Imaging Techniques

Minimally Invasive Endoscopic Surgery for Chronic Diseases of the Maxillary Sinuses
type: item
description: Inflammatory diseases of the mucous membranes of the nasal cavity and paranasal sinuses remain one of the most common pathologies within the spectrum of ENT disorders; among these, lesions of the maxillary sinuses constitute the largest proportion of sinusitis cases. Their high prevalence, tendency toward a chronic and recurrent course, as well as the limited efficacy of traditional treatment methods, underscore the necessity of refining surgical approaches. The aim of this study was to optimize the surgical management of patients with chronic inflammatory diseases of the maxillary sinuses through the implementation of a minimally invasive endoscopic technique. The study involved 101 patients (45 women and 56 men) aged 15 to 75 years. Maxillary sinus cysts were diagnosed in 37 patients; fungal lesions (mycetomas) in 16; polyposis in 37; and chronic purulent sinusitis in 11 patients. All patients underwent an endoscopic procedure performed via a mini-access approach using a Kozlov trocar. The developed technique enabled comprehensive visualization of all compartments of the sinus and the radical removal of pathological formations (cysts, polyps, fungal masses, and foreign bodies) under endoscopic guidance, while ensuring minimal tissue trauma. The application of minimally invasive surgical principles contributed to reduced rehabilitation times and a lower risk of postoperative complications
subject: Articles
  topic: section
subject: Kozlov trocar
  topic: keywords
subject: endoscopic surgery
  topic: keywords
subject: maxillary sinus
  topic: keywords
creator: Madaminova Nigora Ergashevna
rights: Copyright (c) 2026 https://creativecommons.org/licenses/by-nc/4.0
date: 2026-04-15
publication date: 2026-04-15
starting page: 11
ending page: 16

Cardia Insufficiency as a Component of Gastroesophageal Reflux Disease and a Factor in Esophageal Carcinogenesis
type: item
description: Gastroesophageal reflux disease (GERD) is among the most common gastrointestinal disorders and represents an important risk factor for esophageal adenocarcinoma [4,8]. Dysfunction of the lower esophageal sphincter (cardia insufficiency) plays a central role in its development. Long-term exposure of the esophageal mucosa to gastric acid and bile acids leads to chronic inflammation, oxidative stress, and accumulation of genetic alterations, which may ultimately result in malignant transformation [7,12]. This paper reviews current data on the sequence of morphological changes, molecular mechanisms of carcinogenesis, and clinical implications for surveillance
subject: Articles
  topic: section
subject: GERD
  topic: keywords
subject: lower esophageal sphincter
  topic: keywords
subject: Barrett’s esophagus
  topic: keywords
creator: Yusupov O.M.
rights: Copyright (c) 2026 https://creativecommons.org/licenses/by-nc/4.0
date: 2026-04-11
publication date: 2026-04-11
starting page: 7
ending page: 10

Larengeal chondrosarcoma (case report)
type: item
description: Chondrosarcoma of the larynx is a rare type of laryngeal tumor that is often underestimated by patients and diagnosed at late stages of the disease. Clinical, histological, and radiological correlation is necessary for the diagnosis of chondrosarcoma of the larynx. Although the prognosis is relatively favorable, conservative surgical excision with negative margins is recommended. This article describes a case of chondrosarcoma of the larynx in a patient who required total laryngectomy.
subject: Articles
  topic: section
subject: chondrosarcoma of the larynx
  topic: keywords
subject: laryngectomy
  topic: keywords
subject: tracheostomy
  topic: keywords
creator: Abdurakhmanov O.B.
creator: Khudayorov M.S
creator: Soatov U.A
creator: Yuldashev L.T
rights: Copyright (c) 2026 https://creativecommons.org/licenses/by-nc/4.0
date: 2026-04-08
publication date: 2026-04-08
starting page: 1
ending page: 6

Preventive Analysis of Anemia Developing Under the Influence of Environmental Factors (Case Study: The Aral Sea Region)
type: item
description: The desiccation of the Aral Sea and the prolonged impact of the resulting ecological crisis have created adverse conditions for the health of the population in the Aral Sea region. One of the most widespread consequences of this environmental degradation is irondeficiency anemia, particularly among women of reproductive age, pregnant women, nursing mothers, and children. Iron deficiency diminishes the blood's oxygen-carrying capacity, leads to tissue hypoxia, reduces physical and mental performance, and increases the risk of pregnancy complications as well as delays in physical and cognitive development in children. An analysis of epidemiological data (2020–2023) reveals that the prevalence of iron-deficiency anemia among pregnant women in the Aral Sea region reaches 45–50%, while among children under the age of five, it stands at 35–40%. These figures underscore the close correlation between environmental degradation and disturbances in trace element metabolism within the body. Under these conditions, anemia prevention must be approached as a comprehensive strategy encompassing improvements in drinking water quality and nutrition, the fortification of food products with iron and other trace elements, and the enhancement of public health and hygiene awareness among the population. The implementation of these measures will serve to reduce the prevalence of anemia and improve the overall health status of the residents of the Aral Sea region.
subject: Articles
  topic: section
subject: Anemia
  topic: keywords
subject: reproductive health
  topic: keywords
subject: serum ferritin
  topic: keywords
creator: Ruzmetova Guzal Melsovna
creator: Zokirova Kholida Temirzhanovna
rights: Copyright (c) 2026 https://creativecommons.org/licenses/by-nc/4.0
date: 2026-03-13
publication date: 2026-03-13
starting page: 24
ending page: 29

Molecular-Genetic Profiling As A Tool For Personalized Surgical Strategy In Acute Calculous Cholecystitis: A ProspectiveRetrospective Cohort Study
type: item
description: Acute calculous cholecystitis (ACC) is the second most common surgical emergency of the abdominal cavity. Despite advances in laparoscopic technique, the rate of destructive forms and associated complications remains substantial, largely because decisions regarding operative timing rely on subjective clinical criteria. Genetic polymorphisms governing inflammatory response, angiogenesis, and antioxidant defence may predetermine individual susceptibility to rapid gallbladder wall destruction; however, their clinical significance in the Uzbek ethnic population of the Fergana Valley has not previously been investigated.
subject: Articles
  topic: section
subject: acute cholecystitis
  topic: keywords
subject: molecular-genetic predictors
  topic: keywords
subject: laparoscopic cholecystectomy
  topic: keywords
creator: Bunyodjon N. Kurbonboev
creator: Kamolliddin Z. Salakhiddinov
creator: Eduard A. Vasilevskiy
creator: Omonjon T. Dadabaev
rights: Copyright (c) 2026 https://creativecommons.org/licenses/by-nc/4.0
date: 2026-03-05
publication date: 2026-03-05
starting page: 17
ending page: 23

Candidate Gene Polymorphisms As Predictors Of Severe Acute Pancreatitis And Adverse Surgical Outcomes: A Prospective Study In The Uzbek Population
type: item
description: Severe acute pancreatitis (SAP) carries a mortality of up to 40% and its clinical trajectory is only partially explained by conventional scoring systems. Genetic variation in pathways governing vascular response, tissue remodelling, oxidative stress, protease inhibition and drug metabolism may determine individual susceptibility to pancreatic necrosis. The present study aimed to quantify the prognostic contribution of five candidate single-nucleotide polymorphisms (SNPs) - VEGFA G634C (rs2010963), MMP9 Gln279Arg (rs17576), CAT C262T (rs1001179), CYP2C19*2 G681A (rs4244285) and SPINK1 Asn34Ser (rs17107315) - to the development of SAP, infectious complications and adverse surgical outcomes in an ethnically homogeneous Uzbek cohort.
subject: Articles
  topic: section
subject: acute pancreatitis
  topic: keywords
subject: genetic polymorphisms
  topic: keywords
subject: MMP9
  topic: keywords
subject: real-time PCR
  topic: keywords
creator: Khujamberdiyev I.R
creator: Salakhiddinov K.Z
creator: Vasilevskiy E.A
creator: Dadabaev O.T
rights: Copyright (c) 2026 https://creativecommons.org/licenses/by-nc/4.0
date: 2026-03-05
publication date: 2026-03-05
starting page: 9
ending page: 16

SOD2 Gene Polymorphism (Ala16Val, rs4880) as a Predictor of Liver Cirrhosis in Chronic Hepatitis C: The Role of Oxidative Stress in Fibrosis Progression
type: item
description: Oxidative stress is a universal mechanism of hepatocyte damage in chronic hepatitis C (CHC). Manganese superoxide dismutase (SOD2) is the key mitochondrial antioxidant enzyme. The Ala16Val polymorphism (rs4880) affects enzyme import into the mitochondrial matrix. This study aimed to evaluate the association of SOD2 Ala16Val with liver cirrhosis (LC) formation in CHC patients and to assess its relationship with disease severity markers and esophageal varices (EV)
subject: Articles
  topic: section
subject: SOD2
  topic: keywords
subject: Ala16Val
  topic: keywords
subject: rs4880
  topic: keywords
creator: Qaxarov Abduqaxar Nabijanovich
creator: Aleynik Vladimir Alekseyevich
creator: Vasilevskiy Eduard Aleksandrovich
creator: Dadabayev Omonjon Tolibjonovich
rights: Copyright (c) 2026 https://creativecommons.org/licenses/by-nc/4.0
date: 2026-03-05
publication date: 2026-03-05
starting page: 1
ending page: 8

Complications After Surgical Treatment Of Anomalous Pulmonary Venous Connection
type: item
description: Anomalous pulmonary venous connection (APVC) is a congenital heart defect in which one or more pulmonary veins drain into the right atrium or systemic veins instead of the left atrium. This results in oxygenated blood returning to the right heart chambers, where it mixes with deoxygenated venous blood. Without timely surgical intervention, APVC leads to chronic hypoxia and progressive heart failure, affecting the child’s development and survival. Despite successful surgical correction, certain complications may arise in the postoperative period, requiring prompt attention. Literature analysis indicates that studying the outcomes and complications of APVC correction remains a highly relevant clinical issue. The aim of this study was to conduct a comparative evaluation of surgical outcomes for APVC correction depending on the type of defect and to identify the causes of mortality in the early postoperative period
subject: Articles
  topic: section
subject: congenital heart defect
  topic: keywords
subject: anomalous pulmonary venous connection
  topic: keywords
creator: Abrolov Kh.K
creator: Mamatov M.A
creator: Sobirov A.A.
rights: Copyright (c) 2026 https://creativecommons.org/licenses/by-nc/4.0
date: 2026-02-26
publication date: 2026-02-26
starting page: 37
ending page: 44

Comparative Assessment Of Leptin And Adiponectin Dynamics Following Different Bariatric Procedures
type: item
description: This research focuses on evaluating changes in leptin and adiponectin concentrations in individuals undergoing bariatric surgery. These adipocytokines, which regulate fat metabolism and contribute to the progression of obesity, are key elements in its pathophysiology. The study enrolled 44 patients treated at the Endocrinology Department of TMA and Medion Family Hospital between 2022 and 2024. Participants were allocated into two cohorts: those who underwent gastric bypass (n = 19) and those who received sleeve gastrectomy (n = 25). Prior to and following the surgical intervention, biochemical indicators, hormonal profiles, and lipid metabolism parameters were analyzed. Twenty-four months post-operation, patients demonstrated a marked reduction in leptin and a notable rise in adiponectin, underscoring the positive metabolic impact of bariatric procedures in individuals with obesity
subject: Articles
  topic: section
subject: Leptin
  topic: keywords
subject: adiponectin
  topic: keywords
subject: bariatric surgery
  topic: keywords
creator: Shagazatova Barno Khabibullaevna
creator: Rakhimova Sitora Khikmatovna
rights: Copyright (c) 2026 https://creativecommons.org/licenses/by-nc/4.0
date: 2026-02-19
publication date: 2026-02-19
starting page: 31
ending page: 36

Vascular Remodeling And Endothelial Dysfunction After Experimental Splenectomy
type: item
description: To investigate morphofunctional changes in blood vessels after splenectomy in an experimental model. Materials and Methods: The experiment was conducted on adult white male rats divided into a control group and two experimental groups examined on days 14 and 30 after splenectomy. Histological and morphometric methods were applied to assess endothelial integrity, vascular wall structure, and microcirculatory parameters. Results: Splenectomy resulted in endothelial dysfunction, arterial wall remodeling, and significant microcirculatory disturbances. Early changes were predominantly compensatory-adaptive, whereas later stages were characterized by persistent structural alterations, capillary rarefaction, and signs of chronic tissue hypoxia.
subject: Articles
  topic: section
subject: splenectomy
  topic: keywords
subject: endothelium
  topic: keywords
subject: vascular remodeling
  topic: keywords
subject: microcirculation
  topic: keywords
creator: Azimova Masuda Karimovna, PhD
rights: Copyright (c) 2026 https://creativecommons.org/licenses/by-nc/4.0
date: 2026-02-18
publication date: 2026-02-18
starting page: 24
ending page: 30

Assessment Of Changes In Laboratory Indicators After Treatment In Patients Undergoing Hemodyalysis
type: item
description: The article presents a comparative study of laboratory indicators in patients undergoing hemodialysis following complex treatment procedures. The results demonstrate that during renal replacement therapy, patients continue to experience deficiencies in hemoglobin, albumin, calcium, and vitamin D. Conversely, the study shows persistently elevated levels of leukocytes, urea, creatinine, parathyroid hormone, and fibroblast growth factor-23 in the blood serum. These findings emphasize the necessity of an individualized approach to addressing these issues for each patient.
subject: Articles
  topic: section
subject: health care system
  topic: keywords
subject: hemodialysis
  topic: keywords
subject: chronic kidney disease
  topic: keywords
creator: RIZAEV Jasur Alimjanovich
creator: GADAYEV Abdigaffor Gadayevich
creator: MAKHMANOV Lutfullo Saydullayevich
rights: Copyright (c) 2026 https://creativecommons.org/licenses/by-nc/4.0
date: 2026-02-14
publication date: 2026-02-14
starting page: 13
ending page: 23

Improvement Of Trearment Methods For Hypertrophic Gingivitis In Patients With Epilepsy
type: item
description: Patients with epilepsy often demonstrate specific oral and periodontal changes associated with antiepileptic drug therapy, particularly gingival hyperthrophy. To evaluate the dental and periodontal status of patients with epilepsy and to substantiate improved approaches to the treatment of hypertrophic gingivitis in this group. Epilepsy and long-term antiepileptic therapy significantly affect periodontal tissues. Improved preventive and therapeutic approaches aimed at early diagnosis and conservative periodontal treatment are required to prevent tooth loss in epileptic patients
subject: Articles
  topic: section
subject: epilepsy
  topic: keywords
subject: hypertropic gingivitis
  topic: keywords
subject: periodontal diseases
  topic: keywords
creator: Mardonova Dildora Kosimovna
rights: Copyright (c) 2026 https://creativecommons.org/licenses/by-nc/4.0
date: 2026-02-14
publication date: 2026-02-14
starting page: 9
ending page: 12

Challenges and limitations of AI systems in medical decisionmaking:Implications for trust, reliability, and clinical practice
type: item
description: Artificial Intelligence (AI) systems are increasingly used to support medical decisionmaking; however, their reliability in real-world clinical settings remains constrained by several fundamental limitations. While AI models often perform well in controlled research environments, their application in high-stakes clinical decisions raises concerns related to data quality, model confidence, and transparency. Clinical datasets are frequently biased, incomplete, or context-specific, which limits the generalizability of AIdriven recommendations across diverse patient populations. In addition, many AI systems present predictions with high confidence while failing to communicate uncertainty, increasing the risk of automation bias and overreliance in clinical practice. The lack of explainability in advanced AI models further complicates trust, accountability, and effective human–AI collaboration. This paper examines the key challenges and limitations of AI systems in medical decision-making, focusing on data-related constraints, model overconfidence, and explainability. It argues that the safe integration of AI into clinical practice requires trustworthy, uncertainty-aware, and human-centered decision-support systems rather than purely accuracy-driven models
subject: Articles
  topic: section
subject: Artificial Intelligence
  topic: keywords
subject: Medical Decision-Making
  topic: keywords
subject: Trustworthy AI
  topic: keywords
creator: Tastanova Saida
creator: Feruza Ortikova
creator: Suhrobjon Shokirov
rights: Copyright (c) 2026 https://creativecommons.org/licenses/by-nc/4.0
date: 2026-02-13
publication date: 2026-02-13
starting page: 1
ending page: 8

Factors Affecting Survival In Patients Undergoing Hemodialysis
type: item
description: The article examines how age, gender, and several biochemical parameters affect survival to varying degrees in patients undergoing hemodialysis. The results indicate that a number of clinical and demographic factors have a significant negative impact on patient survival. It was found that for every 10-year increase in age, the risk of death rises by 1.61 times, demonstrating a significantly lower survival rate in elderly patients. The 28% higher risk of death in men compared to women is attributed to the higher prevalence of cardiovascular diseases among men. The presence of diabetes mellitus was found to nearly double the risk of death, and in hemodialysis patients, this disease was identified as an independent unfavorable prognostic factor. Chronic heart failure was determined to increase the risk of death by 2.5 times, making it one of the strongest negative factors among those analyzed.
subject: Articles
  topic: section
subject: hemodialysis
  topic: keywords
subject: chronic kidney disease
  topic: keywords
subject: fibroblast-23
  topic: keywords
creator: MAKHMANOV Lutfullo Saydullayevich
creator: GADAYEV Abdigaffor Gadayevich
creator: GADAYEVA Nilufar Abdigaffarovna
rights: Copyright (c) 2026 https://creativecommons.org/licenses/by-nc/4.0
date: 2026-01-28
publication date: 2026-01-28
starting page: 16
ending page: 23

Identification Of Morphological Changes In The Differentiation Processes Occurring In The Ovary In The Early Postpartum Period
type: item
description: This article is devoted to the identification of morphological changes that occur in the histotopography of the ovaries in girls in the early postpartum period. As a material, the ovaries of girls whose abdomen died of asphyxia and pneumopathy were studied using methods of general histology, histochemistry and morphometry. It was noticed that in the cortical layer of the ovary of newborns, rudimentary eggs are located in a dense state, follicular structures are formed as a result of the proliferation of granulose cells in the areas bordering the stratum corneum, and between them, i.e. in the interstitium, there are pregranular and celemic cells of different densities. It was found that by the age of 3 months in infants, the primary eggs in the ovarian mucosa are thinning, most of them undergo degenerative and destructive changes, bundles of fibrous connective tissue are formed in the intermediate tissue. From the earliest postpartum period, infants experience destruction and atresia of a part of the embryonic eggs that perform a reproductive function in the ovary, granulosis and proliferation of cells of the uterine tissue in the intermediate tissue
subject: Articles
  topic: section
subject: infant
  topic: keywords
subject: ovary
  topic: keywords
subject: histology
  topic: keywords
subject: histochemistry
  topic: keywords
creator: Akramova M.Yu
rights: Copyright (c) 2026 https://creativecommons.org/licenses/by-nc/4.0
date: 2026-01-20
publication date: 2026-01-20
starting page: 11
ending page: 15

Integration of Artificial Intelligence and Modern Medicine
type: item
description: This academic article deeply analyzes the integration of artificial intelligence (AI) and modern medicine. It examines AI's main applications in diagnostics, drug discovery, and personalized medicine. The advantages of this integration for healthcare systems, such as increased efficiency, accuracy, and new opportunities, are thoroughly discussed. Concurrently, key challenges and limitations, including data management, ethical dilemmas, and regulatory constraints, are critically explored. Finally, the future prospects of AI in medicine, development trends, and recommendations for ensuring the safe, equitable, and effective integration of this transformative technology are presented
subject: Articles
  topic: section
subject: Artificial intelligence
  topic: keywords
subject: Medicine
  topic: keywords
subject: Diagnostics
  topic: keywords
creator: Ergasheva Madina Khusniddin qizi
creator: Abdujabborova Diyora Djalaliddin qizi
rights: Copyright (c) 2026 https://creativecommons.org/licenses/by-nc/4.0
date: 2026-01-16
publication date: 2026-01-16
starting page: 6
ending page: 10

Melphalan-associated enteropathy in recipients of allogeneic hematopoietic stem cell transplantation: analysis of our own data and a literature review
type: item
description: The widespread use of high-dose melphalan in conditioning regimens for allogeneic hematopoietic stem cell transplantation (allo-HSCT) has led to an increased incidence of melphalan-associated enteropathy (MAE), a severe toxic intestinal injury. A key challenge in management is its differentiation from acute graft-versus-host disease (GVHD)
subject: Articles
  topic: section
subject: melphalan-associated enteropathy
  topic: keywords
subject: allogeneic HSCT
  topic: keywords
subject: graft-versus
  topic: keywords
subject: intestinal toxicity
  topic: keywords
creator: S.B. Mukhammadiev
creator: S.S. Asilov
creator: K.A. Olimjonov
creator: N.Kh. Kakharova
creator: G.Z. Makhamadalieva
creator: A.A. Kayumov
creator: M.Yu. Drokov
rights: Copyright (c) 2026 https://creativecommons.org/licenses/by-nc/4.0
date: 2026-01-14
publication date: 2026-01-14
starting page: 1
ending page: 5

Topographic And Anatomical Pathways Of Tumor Dissemination In The Female Reproductive Organs
type: item
description: The anatomy of the female pelvis and reproductive organs constitutes a highly complex topographic–anatomical system that plays a pivotal role in understanding the clinical behavior and dissemination patterns of malignant tumors. Accurate knowledge of pelvic anatomy is of particular importance in gynecologic oncology, where surgical strategy, the extent of lymphadenectomy, identification of metastatic routes, and prognostic assessment are directly influenced by individual variations in vascular supply, lymphatic drainage, organ syntopy, and fascial and cellular compartments.
subject: Articles
  topic: section
subject: uterus
  topic: keywords
subject: vagina
  topic: keywords
subject: blood vessels
  topic: keywords
creator: Jalolov Oybek Kamoliddinovich
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc/4.0
date: 2025-12-26
publication date: 2025-12-26
starting page: 38
ending page: 44

Evaluation of the Effectiveness of Immunotherapy in Combination with Conventional Treatment Modalities in Early-Stage Breast Cancer
type: item
description: Breast cancer remains the most frequently diagnosed malignant disease among women worldwide and continues to represent a major cause of cancer-related morbidity and mortality. Despite significant advances in screening, early detection, and multidisciplinary treatment, breast cancer poses ongoing clinical challenges due to its biological heterogeneity and variable response to therapy. Early-stage breast cancer, generally defined as stages I–II according to the TNM classification, is associated with favorable survival outcomes; however, a proportion of patients still experience disease recurrence, progression, or treatment-related toxicity
subject: Articles
  topic: section
subject: outcomes
  topic: keywords
subject: cancer poses
  topic: keywords
subject: disease
  topic: keywords
creator: Urmanbaeva Dilbaroy Abdulkosimovna
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc/4.0
date: 2025-12-25
publication date: 2025-12-25
starting page: 32
ending page: 37

Analysis Of The Effectiveness Of Total Neoadjuvant Therapy In The Treatment Of Patients With Pancreatic Cancer
type: item
description: Pancreatic cancer remains one of the most aggressive and lethal malignancies in modern oncology and continues to pose a major clinical challenge worldwide. Pancreatic ductal adenocarcinoma (PDAC) accounts for more than 90% of all pancreatic malignancies and is characterized by rapid disease progression, early metastatic spread, and resistance to many conventional treatment modalities. Despite representing a smaller proportion of overall cancer incidence, pancreatic cancer ranks among the leading causes of cancer-related mortality, with five-year survival rates remaining below 15% in most populations. This unfavorable prognosis reflects a combination of late diagnosis, complex tumor biology, and limited therapeutic effectiveness
subject: Articles
  topic: section
subject: diagnosis
  topic: keywords
subject: mortality
  topic: keywords
subject: biology
  topic: keywords
subject: therapeutic
  topic: keywords
creator: Akhmadzhanov Elmurodjon Burkhanidinovich
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc/4.0
date: 2025-12-25
publication date: 2025-12-25
starting page: 27
ending page: 31

Radiological Approaches to Improve Detection of Delayed Hip Joint Complications in Post-COVID Patients
type: item
description: The objective of this study is to improve the diagnostic effectiveness of radiological methods in identifying late-stage post-COVID pathologies of the hip joint. This includes defining specific radiological features and patterns that characterize these complications, thereby aiding in early detection, accurate staging, and appropriate management of postCOVID hip joint diseases. Timely and precise diagnosis is essential to prevent progression to severe joint damage and reduce the risk of disability.
subject: Articles
  topic: section
subject: Timely
  topic: keywords
subject: essential
  topic: keywords
subject: diagnosis
  topic: keywords
creator: Ablyazov A.A
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc/4.0
date: 2025-12-25
publication date: 2025-12-25
starting page: 24
ending page: 26

Optimizing Acute Pyelonephritis Diagnosis through Doppler Ultrasound Imaging
type: item
description: This article describes the way of improving the diagnosis of cute pyelonephritis, which is a bacterial infection of the renal pelvis and parenchyma most commonly seen in young women. It remains common and continues to have significant morbidity in certain groups of patients, using doppleroghraphy.
subject: Articles
  topic: section
subject: acute pyelonephritis
  topic: keywords
subject: magnetic resonance
  topic: keywords
subject: urinary tract infection
  topic: keywords
creator: Yakubov N.I
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc/4.0
date: 2025-12-25
publication date: 2025-12-25
starting page: 18
ending page: 23

Ultrasound-Based Assessment in the Diagnosis of Hydronephrosis
type: item
description: Hydronephrosis refers to an abnormal enlargement of the renal pelvicalyceal system resulting from obstruction or disturbance of normal urinary drainage. This condition may present in either acute or chronic forms and, if not identified and managed promptly, can progress to permanent renal impairment and eventual kidney failure. Ultrasonography is widely recognized as the primary imaging technique for assessing hydronephrosis due to its broad accessibility, noninvasive nature, affordability, and absence of ionizing radiation. The aim of the present study is to evaluate the clinical significance and diagnostic effectiveness of ultrasound in the identification, differentiation, and follow-up of hydronephrosis across various underlying causes
subject: Articles
  topic: section
subject: hydronephrosis
  topic: keywords
subject: ultrasound
  topic: keywords
subject: renal pelvis
  topic: keywords
creator: Nurmativ Sanjarbek
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc/4.0
date: 2025-12-25
publication date: 2025-12-25
starting page: 15
ending page: 17

A Critical Analysis Of The Phases Of Anesthesia In An Organized Health Care System
type: item
description: Anesthesia is a cornerstone of modern surgical practice, enabling pain-free and safe operative procedures. This paper presents a critical analysis of the phases of anesthesia within an organized health care system, emphasizing their clinical significance, safety considerations, and interprofessional coordination. The phases of anesthesia preoperative assessment, induction, maintenance, and recovery are examined in relation to standardized protocols, patient safety measures, and quality assurance frameworks. The study highlights the role of structured health care systems in optimizing anesthetic outcomes through effective communication, evidence-based practice, and continuous monitoring. Challenges such as patient variability, resource limitations, and perioperative risks are critically evaluated, alongside strategies for improvement including adherence to guidelines, technological advancements, and workforce training. By analyzing anesthesia care across its phases, the study concluded that the phases of anesthesia preoperative assessment, induction, maintenance, and recovery are interdependent components of safe and effective anesthetic care. This critical analysis demonstrates that the success of anesthesia management is largely influenced by the level of organization within the health care system. An organized health care structure supports standardized protocols, skilled personnel, and effective. One of the recommendations made was that, Health care institutions should prioritize comprehensive preoperative evaluations to identify risk factors, optimize patient conditions, and plan individualized anesthetic care.
subject: Articles
  topic: section
subject: Phases of Anesthesia
  topic: keywords
subject: Organized Health Care System
  topic: keywords
creator: Ojum S
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc/4.0
date: 2025-12-18
publication date: 2025-12-18
starting page: 7
ending page: 14

Modern Aspects Of Etiology, Pathogenesis, Diagnosis And Treatment Of Chronic Generalized Periodontitis
type: item
description: Chronic Generalized periodontitis is one of the most common inflammatory and destructive pathologies of periodontal tissues and is a leading cause of premature tooth loss in adults. The disease is characterized by a multifactorial etiology, complex pathogenesis, and a close relationship with general somatic pathology. This article presents an analysis of current data on the etiological factors and pathogenetic mechanisms of the development of chronic generalized periodontitis. The clinical manifestations of the disease depending on the severity, modern diagnostic methods, including clinical, radiological, and laboratory approaches are considered. Particular attention is paid to the principles of comprehensive treatment, including conservative, surgical, and preventive measures aimed at stabilizing the pathological process and preventing relapse. The need for an individualized and interdisciplinary approach to the management of patients with chronic periodontitis is demonstrated. generalized periodontitis.
subject: Articles
  topic: section
subject: Chronic generalized periodontitis
  topic: keywords
subject: periodontal diseases
  topic: keywords
subject: inflammation
  topic: keywords
creator: Azimov Saidabror Kayumjon ugli
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc/4.0
date: 2025-12-17
publication date: 2025-12-17
starting page: 4
ending page: 6

Bees Poison And His Joint In Diseases Effect
type: item
description: This article joint diseases in treatment bees healing of poison ( apitoxin ). effect him to the joints and to the organism effect effect will be lit. Bees by calling treatment the main type of treatment methods advantages is displayed .
subject: Articles
  topic: section
subject: apitoxin polypeptides
  topic: keywords
subject: mellitin
  topic: keywords
subject: apamin
  topic: keywords
creator: Makhamadkhodjayeva.MA
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc/4.0
date: 2025-12-12
publication date: 2025-12-12
starting page: 1
ending page: 3

Diastolic Dysfunction of the Left and Right Ventricles in Patients with Ischemic Heart Disease at the Early Stages of Chronic Heart Failure
type: item
description: The concept of “diastolic dysfunction” is based on both structural and functional remodeling of cardiomyocytes and the interstitial matrix, leading to increased myocardial stiffness [2,4]. Unlike systole, during which Ca²⁺ ions are actively released from the sarcoplasmic reticulum into the cytosol, myocardial relaxation is an energy-dependent process associated with the active transport of Ca²⁺ ions back into the sarcoplasmic reticulum against a concentration gradient [10]. This mechanism explains why disturbances in myocardial relaxation occur earlier than systolic dysfunction, particularly under conditions of myocardial ischemia in ischemic heart disease (IHD) [3,6,9]. The mechanisms underlying impaired diastolic function in IHD can be conventionally divided into two categories: disorders of active relaxation caused by the development of cardiosclerosis and those associated with myocardial ischemia
subject: Articles
  topic: section
subject: systole
  topic: keywords
subject: disorders
  topic: keywords
subject: myocardial relaxation
  topic: keywords
subject: cardiosclerosis
  topic: keywords
creator: Tashtemirova Irodaxon Makambayevna
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc/4.0
date: 2025-11-29
publication date: 2025-11-29
starting page: 25
ending page: 29

A Clinical Study Of The Method Of Early Diagnosis Of Coronary Heart Disease
type: item
description: Recently, the issue of early diagnosis of coronary heart disease (CHD) remains the most urgent task of cardiology. The gas analytical method for the analysis of exhaled air (EA) is a new approach to solving this problem [1,5,11]. Our clinical studies of this technique, used to develop a non-invasive method for the diagnosis of coronary heart disease, have led to the following main results: CHD is accompanied by impaired metabolism of biogenic amines [6], volatile biogenic amines are found in the composition of explosives in patients with CHD [1, 2], the content of diethylamine in explosives increases most significantly in patients with postinfarction cardiosclerosis (PICS) [7], secondary amines (SA) can be formed as a result of the reduction of Schiff bases (SHO) under acidosis conditions in the cellular sarcosomes of the cardiac muscle [8,9]. However, the nature of the dependence of the kinetic parameters of SA formation on the degree and scale of ischemic myocardial zones remains unclear.
subject: Articles
  topic: section
subject: Coronary heart disease
  topic: keywords
subject: degree
  topic: keywords
subject: explosives
  topic: keywords
creator: Kodirova G.I
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc/4.0
date: 2025-11-27
publication date: 2025-11-27
starting page: 21
ending page: 24

Osteocalcin As A Marker Of Bone Metabolism Disorders In Children With Juvenile Idiopathic Arthritis
type: item
description: To determine the relationship between osteocalcin and markers of inflammation and bone metabolism in children with juvenile idiopathic arthritis (JIA).
subject: Articles
  topic: section
subject: children
  topic: keywords
subject: juvenile
  topic: keywords
subject: relationship
  topic: keywords
creator: Dinmukhammadieva Dilorom Rakhimdjanovna
creator: Shadiyeva Soadat Ulmasovna
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc/4.0
date: 2025-11-10
publication date: 2025-11-10
starting page: 18
ending page: 20

Tumors Of The Head And Neck: Detection At Stage T Using Modern Imaging Techniques
type: item
description: Tumors of the head and neck are characterized by an aggressive course and a high risk of late diagnosis. Despite advances in oncology, most patients are admitted to specialized centers at stages T2–T4, when the effectiveness of treatment is significantly reduced. The detection of tumors at the T₀ stage, when there are no clinical manifestations yet, but morphological and metabolic changes are already forming, is a key area of modern oncorentgenology . The article discusses the possibilities of magnetic resonance imaging (MRI), computed tomography (CT) and positron emission tomography (PET/CT) in the diagnosis of head and neck tumors in the early stages. The results of clinical observations are presented, showing that the use of multiparametric MRI and hybrid technologies can increase the detectability of subclinical forms up to 92%.
subject: Articles
  topic: section
subject: head and neck tumors
  topic: keywords
subject: stage T
  topic: keywords
subject: early diagnosis
  topic: keywords
creator: Akhmadzhanov Elmurodjon Burkhanidinovich
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc/4.0
date: 2025-11-06
publication date: 2025-11-06
starting page: 14
ending page: 17