Iron Toxicity in Neurological Diseases: A Key or Standby

Zahraa Naje; Rana M. Hameed; Atheer Hameid Odda; Amer Fadhil Alhaideri

Authors

Zahraa Naje Biochemistry Department, College of Medicine, University of Kerbala, Karbala, Iraq
Rana M. Hameed Biochemistry Department, College of Medicine, University of Kerbala, Karbala, Iraq
Atheer Hameid Odda Biochemistry Department, College of Medicine, University of Kerbala, Karbala, Iraq
Amer Fadhil Alhaideri Professor of Psychiatry College of Medicine, University of Kerbala, Karbala, Iraq

Keywords:

Ferroptosis, Neurodegeneration disease, Alzheimer's disease

Abstract

Ferroptosis is a recently identified type of regulated cell death. Specifically, it is a nonapoptotic, iron-dependent, oxidative cell death mechanism that was proposed by Dixon. There are several prospects regarding ferroptosis in the nervous system. Importantly, there is a need for chemical probes or biomarkers capable of elucidating the ferroptosis mechanism to determine its role in the nervous system given the quick cell death occurrence and difficulty in obtaining appropriate neurons. This review would aim to highlighting the role of free iron, their transported such divalent metal transporter 1 (DMT1) and ferritin in Neurodegeneration disease