SOD2 Gene Polymorphism (Ala16Val, rs4880) as a Predictor of Liver Cirrhosis in Chronic Hepatitis C: The Role of Oxidative Stress in Fibrosis Progression

Authors

  • Qaxarov Abduqaxar Nabijanovich Andijan State Medical Institute, Uzbekistan
  • Aleynik Vladimir Alekseyevich Andijan State Medical Institute, Uzbekistan
  • Vasilevskiy Eduard Aleksandrovich Andijan State Medical Institute, Uzbekistan
  • Dadabayev Omonjon Tolibjonovich Andijan State Medical Institute, Uzbekistan

Keywords:

SOD2, Ala16Val, rs4880

Abstract

Oxidative stress is a universal mechanism of hepatocyte damage in chronic hepatitis C (CHC). Manganese superoxide dismutase (SOD2) is the key mitochondrial antioxidant enzyme. The Ala16Val polymorphism (rs4880) affects enzyme import into the mitochondrial matrix. This study aimed to evaluate the association of SOD2 Ala16Val with liver cirrhosis (LC) formation in CHC patients and to assess its relationship with disease severity markers and esophageal varices (EV)

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Published

2026-03-05

Issue

Vol. 54 (2026): EMRP

Section

Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

How to Cite

SOD2 Gene Polymorphism (Ala16Val, rs4880) as a Predictor of Liver Cirrhosis in Chronic Hepatitis C: The Role of Oxidative Stress in Fibrosis Progression. (2026). Eurasian Medical Research Periodical, 54, 1-8. https://geniusjournals.org/index.php/emrp/article/view/7354