Relationship Between the Severity of SARS-coV-2 Infection and Interleukin-10

Ghadeer Abbas Laibi Jakal; mawj raad abd_alkarim yasir; Ghaith Basim Kareem Kalaf; Abdullah maher hamdi said; Abtsam Adnan Aziz Dakhil

Authors

Ghadeer Abbas Laibi Jakal University of Technology/Department of Applied Sciences Biotechnology Branch
mawj raad abd_alkarim yasir Al_Nahrain University College of Biotechnology / Molecular and medical biotechnologies
Ghaith Basim Kareem Kalaf Al Qasim Green University College of BiotechnologyDepartment of Genetic Engineering
Abdullah maher hamdi said University of Baghdad College of science Department of biotechnology
Abtsam Adnan Aziz Dakhil Baghdad university science college biotechnology Department

Keywords:

SARS-coV-2, COVID-19 pandemic, IL-10 levels

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly spread worldwide, leading to the COVID-19 pandemic. Understanding the host's immunological response to SARS-CoV-2 infection is critical for finding effective treatments. Interleukin10 is an anti-inflammatory cytokine that control immune responses. However, its exact involvement in the context of SARS-CoV-2 infection severity is unknown.We conducted a systematic review and meta-analysis to understand better the association between SARSCoV-2 infection severity and IL-10 levels. A comprehensive search was conducted across various databases to identify relevant published research. The studies included analyses of IL-10 levels in COVID-19 patients, stratified by disease severity. The results of our investigations show a positive association between the severity of SARS-CoV-2 infection and IL-10 levels, indicating that IL-10 may play a role in disease etiology. More research is required to comprehend the molecular foundation of this association and to explore the therapeutic prospects of targeting IL-10 in COVID-19 treatment. Having this knowledge could help develop particular treatment plans for COVID-19 patients based on their immune profiles