Comparative Evaluation of MMP and Cystatin C in Chronic Nephritic Syndrome in Children

Bazarova Nigina Sobirzhonovna; Mamatkulov Bakhrom Bosimovich; Khalikova Gulnoza Asadovna

Authors

Bazarova Nigina Sobirzhonovna Assistant of the Department of Propaedeutics of Children’s Diseases. Samarkand State Medical Institute. Samarkand, Uzbekistan
Mamatkulov Bakhrom Bosimovich Head of the Department of Nephrology, Associate Professor Republican National Children's Center, Tashkent Uzbekistan
Khalikova Gulnoza Asadovna Assistant of the Department of Propaedeutics of Children’s Diseases. Samarkand State Medical Institute. Samarkand, Uzbekistan

Keywords:

Chronic glomerulonephritis, matrix metalloproteinase, Cystatin S., tissue inhibitor

Abstract

Currently, methods of molecular diagnostics have begun to be actively developed, which not only complement traditional research methods, but also provide insight from the point of view of molecular pathophysiology. It is expected that a key role in the diagnosis of kidney disease is increasingly played by the identification of genes and their changes in the course of the disease, which predict the course of diseases. Changes in the chromosomal polymorphic genes of matrix metalloproteinase and its tissue inhibitors, as well as their effect on the glomerular filtration rate in children with chronic glomerulonephritis, determine the prognosis of the disease