Clinical And Morphological Parallels Between Helicobacter-Associated Gastroduodenal Disease and Fatty Liver Disease (FLD) (Literature Review)

Oybek Hasanov Gafurovich; Rakhmonova Mokhigul Shodikulovna; Tokhirjonova Aziza Tokhirjon qizi; Sangirova Fotima Abdurakhmon kizi

Authors

Oybek Hasanov Gafurovich Assistant Professor, Samarkand State Medical University
Rakhmonova Mokhigul Shodikulovna 319 group of the Faculty of Medicine Samarkand State Medical University
Tokhirjonova Aziza Tokhirjon qizi 319 group of the Faculty of Medicine Samarkand State Medical University
Sangirova Fotima Abdurakhmon kizi 319 group of the Faculty of Medicine Samarkand State Medical University

Keywords:

Non-alcoholic, liver disease, morphological, gastroduodenal

Abstract

Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease; its detection in the general population has reached global proportions. Although the disease has a relatively mild course in its early stages, the development of non-alcoholic steatohepatitis, cirrhosis and hepatocellular carcinoma during its natural course leads to a worse long-term prognosis. A growing body of evidence suggests that NAFLD has a complex, multifaceted aetiology involving many factors, including genetic factors. In this review we focus on a genetic component of NAFLD, namely the role of PNPLA3 gene polymorphisms in the development and course of the disease as well as its progression states such as nonalcoholic steatohepatitis, cirrhosis and hepatocellular carcinoma.